Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation

• Published in: Journal of neuroinflammation Vol. 20; no. 1; pp. 165 - 21
• Main Authors: Chen, Yijun, Yu, Yang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.07.2023; BioMed Central; BMC
• Subjects: Age factors in disease; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides; Analysis; Brain; Care and treatment; Cell activation; Clinical trials; Cognitive ability; Dementia disorders; Diagnosis; Drug development; Glia; Glial cells; Humans; Inflammation; Inflammation - complications; Kinases; Neurodegeneration; Neurodegenerative diseases; Neurofibrillary tangles; Neuroinflammation; Neuroinflammatory Diseases; Neuronal-glial interactions; Neurophysiology; Pathology; Patient outcomes; Post-translation; Review; Senile plaques; Tau phosphorylation; Tau propagation; Tau protein; Tau proteins; tau Proteins - metabolism; Tauopathies; Tauopathies - pathology; Therapeutic applications; Therapeutic targets; Translation; β-Amyloid; China; Tau phosphorylation; Tauopathies; Alzheimer’s disease; Astrocytes; Neuroinflammation; Tau propagation; Glia; Microglia

Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated β-amyloid (Aβ) and hyperphosphorylated tau protein, respectively. In the past few decades,...