Targeting PAR2-mediated inflammation in osteoarthritis: a comprehensive in vitro evaluation of oleocanthal’s potential as a functional food intervention for chondrocyte protection and anti-inflammatory effects

• Published in: BMC musculoskeletal disorders Vol. 25; no. 1; pp. 769 - 23
• Main Authors: Patnaik, Rajashree, Varghese, Riah, Jannati, Shirin, Naidoo, Nerissa, Banerjee, Yajnavalka
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.10.2024; BioMed Central; BMC
• Subjects: Aldehydes; Analysis; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Antibiotics; Apoptosis; Bioenergetics; Bone marrow; Cartilage; Cartilage cells; Cartilage diseases; Cell culture; Cell differentiation; Cell growth; Cell receptors; Cell viability; Cells, Cultured; Cellular signal transduction; Chondrocytes; Chondrocytes - drug effects; Chondrocytes - metabolism; Consent; Cyclopentane Monoterpenes - pharmacology; Diet therapy; Down-regulation; Enzymes; Ethylenediaminetetraacetic acid; Flow cytometry; Fluorescent indicators; Functional Food; Functional foods; Functional foods & nutraceuticals; Gene expression; Genes; Health aspects; Human subjects; Humans; In vitro techniques; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Joint diseases; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Membrane potential; Membrane Potential, Mitochondrial - drug effects; Mesenchymal stem cells; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Monocyte chemoattractant protein 1; Musculoskeletal diseases; Nitrogen; Nonsteroidal anti-inflammatory drugs; Oleocanthal; Olive oil; Osteoarthritis; Osteoarthritis - drug therapy; Osteoarthritis - metabolism; Pathogenesis; Penicillin; Phenolic compounds; Phenols; Polymerase chain reaction; Protease-activated receptor 2 (PAR-2); Proteases; Rankings; Receptor, PAR-2 - metabolism; Scientific equipment and supplies industry; Stem cells; Therapeutics, Experimental; Tumor necrosis factor-TNF; Canada; California; United States; Massachusetts; Illinois; India; Mumbai India; United States > US; Germany; Cartilage; Signal transduction; Inflammation mediators; In vitro techniques; Chondrocytes; Phenols; Extracellular matrix; Oleocanthal; Anti-inflammatory agents; Osteoarthritis; Protease-activated receptor 2 (PAR-2); Mitochondrial membrane potential

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by chronic inflammation and progressive cartilage degradation, ultimately leading to joint dysfunction and disability. Oleocanthal (OC), a bioactive phenolic compound derived from extra virgin olive oil, has garnered signifi...