Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome

• Published in: NeuroImage (Orlando, Fla.) Vol. 183; pp. 438 - 455
• Main Authors: Alderson, Thomas H., Bokde, Arun L.W., Kelso, J.A. Scott, Maguire, Liam, Coyle, Damien
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Brain mapping; Brain research; Cognition & reasoning; Cognitive ability; Computational neuroscience; Connectome - methods; Databases, Factual; Dementia; Dementia disorders; Diffusion Tensor Imaging - methods; DTI; Female; Functional magnetic resonance imaging; Humans; Image Processing, Computer-Assisted - methods; Kuramoto; Magnetic Resonance Imaging - methods; Male; Medical imaging; Metastability; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - pathology; Nerve Net - physiopathology; Neural networks; Neurodegenerative diseases; Pharmaceutical industry; R&D; Research & development; Structural connectome; Whole-brain modelling; Southern California; United States > US; DTI; Kuramoto; Alzheimer's disease; Whole-brain modelling; Metastability; Structural connectome

Current theory suggests brain regions interact to reconcile the competing demands of integration and segregation by leveraging metastable dynamics. An emerging consensus recognises the importance of metastability in healthy neural dynamics where the transition between network states over time is dep...