BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation

• Published in: Molecular cell Vol. 52; no. 3; pp. 393 - 405
• Main Authors: Cundell, Michael J, Bastos, Ricardo Nunes, Zhang, Tongli, Holder, James, Gruneberg, Ulrike, Novak, Bela, Barr, Francis A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.11.2013; Cell Press
• Subjects: anaphase; Animalia; CDC2 Protein Kinase - metabolism; chromosome segregation; Chromosome Segregation - genetics; Chromosomes - genetics; Cyclin B - metabolism; cyclins; cytokinesis; Cytokinesis - genetics; dephosphorylation; HeLa Cells; Humans; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Mitosis - genetics; Phosphoric Monoester Hydrolases - metabolism; Protein Phosphatase 2 - genetics; Protein Phosphatase 2 - metabolism; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Protein Tyrosine Phosphatases; separase; Separase - genetics; Separase - metabolism; Signal Transduction - genetics; yeasts

Cytokinesis follows separase activation and chromosome segregation. This order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p dephosphorylates key conserved Cdk1-substrates exemplified by the anaphase spindle-elongation protein Ase1p. However, in metazoans, MEN and Cdc14...