Efficacy and safety of autologous platelet-rich plasma for diabetic foot ulcer healing: a systematic review and meta-analysis of randomized controlled trials

• Published in: Journal of orthopaedic surgery and research Vol. 18; no. 1; pp. 370 - 15
• Main Authors: Deng, Juan, Yang, Mei, Zhang, Xingyu, Zhang, Hongmin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.05.2023; BioMed Central; BMC
• Subjects: Amputation; Analysis; Blood platelets; Care and treatment; Clinical trials; Cytokines; Diabetes; Diabetes Mellitus; Diabetic foot; Diabetic Foot - therapy; Diabetic foot ulcer; Foot diseases; Growth factors; Health aspects; Humans; Information management; Intercellular Signaling Peptides and Proteins; Leg ulcers; Meta-analysis; Orthopedics; Physiological aspects; Plasma; Platelet-Rich Plasma; Platelets; Randomized controlled trials; Randomized Controlled Trials as Topic; Systematic Review; Wound Healing; Wounds and injuries; United States > US; Diabetic foot ulcer; Platelet-rich plasma; Meta-analysis; Randomized controlled trials

The occurrence of a diabetic foot ulcer (DFU) is a significant complication of diabetes that often precedes the need for amputation. Autologous platelet-rich plasma (Au-PRP), a substance abundant in various growth factors and cytokines, is increasingly being recognized as a promising method for prom...