Glu333 in rabies virus glycoprotein is involved in virus attenuation through astrocyte infection and interferon responses

• Published in: iScience Vol. 25; no. 4; p. 104122
• Main Authors: Itakura, Yukari, Tabata, Koshiro, Morimoto, Kohei, Ito, Naoto, Chambaro, Herman M., Eguchi, Ryota, Otsuguro, Ken-ichi, Hall, William W., Orba, Yasuko, Sawa, Hirofumi, Sasaki, Michihito
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.04.2022; Elsevier
• Subjects: Cellular neuroscience; Immunology; Virology; Cellular neuroscience; Immunology; Virology

The amino acid residue at position 333 of the rabies virus (RABV) glycoprotein (G333) is a major determinant of RABV pathogenicity. Virulent RABV strains possess Arg333, whereas the attenuated strain HEP-Flury (HEP) possesses Glu333. To investigate the potential attenuation mechanism dependent on a...