Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C

• Published in: Cancer letters Vol. 402; pp. 190 - 202
• Main Authors: Chang, Tzu-Hua, Tsai, Meng-Feng, Gow, Chien-Hung, Wu, Shang-Gin, Liu, Yi-Nan, Chang, Yih-Leong, Yu, Sung-Liang, Tsai, Hsing-Chen, Lin, Shih-Wen, Chen, Yen-Wei, Kuo, Po-Yen, Yang, Pan-Chyr, Shih, Jin-Yuan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.08.2017; Elsevier Limited
• Subjects: 3' Untranslated Regions; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Adenocarcinoma - secondary; Adenocarcinoma of Lung; Animals; Antineoplastic Agents - pharmacology; Apoptosis; Arrays; Binding Sites; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - secondary; Cell cycle; Cell growth; Cell Line, Tumor; Cell Movement - drug effects; Cisplatin - pharmacology; Epithelial-mesenchymal transition (EMT); Gene expression; Gene Expression Regulation, Neoplastic; Hematology, Oncology and Palliative Medicine; Humans; Kaplan-Meier Estimate; Kinases; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Medical prognosis; Mesenchyme; Metastases; Metastasis; Mice, Inbred NOD; Mice, SCID; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miR-137; miRNA; Neoplasm Invasiveness; Non-small cell lung cancer (NSCLC); Non-small cell lung carcinoma; Promoter Regions, Genetic; Protein Binding; RNA Interference; Signal Transduction; Slug; Snail Family Transcription Factors - genetics; Snail Family Transcription Factors - metabolism; Survival; TFAP2C; Thyroid cancer; Time Factors; Transcription Factor AP-2 - genetics; Transcription Factor AP-2 - metabolism; Transcription factors; Transfection; Up-Regulation; Epithelial-mesenchymal transition (EMT); miR-137; TFAP2C; Slug; Non-small cell lung cancer (NSCLC)

The epithelial-mesenchymal transition (EMT) regulator, Slug, plays multifaceted roles in controlling lung cancer progression, but its downstream targets and mechanisms in promoting lung cancer progression have not been well defined. In particular, the miRNAs downstream of Slug in non-small cell lung...