Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer

• Published in: Journal of biomedical science Vol. 30; no. 1; pp. 47 - 19
• Main Authors: Li, Peisi, Zhou, Dawang, Chen, Dongwen, Cheng, Yikan, Chen, Yuan, Lin, Zhensen, Zhang, Xi, Huang, Zhihong, Cai, Jiawei, Huang, Wenfeng, Lin, Yanyun, Ke, Haoxian, Long, Jiahui, Zou, Yifeng, Ye, Shubiao, Lan, Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.06.2023; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animal models; Animals; Antibodies; Anticancer properties; Antigens; Antineoplastic Agents; Biomarkers; CD8 antigen; CD8+ T cells; CD8-Positive T-Lymphocytes; Cell culture; Cell growth; Cell proliferation; Colon cancer; Colonic Neoplasms; Colorectal cancer; Colorectal carcinoma; Cytotoxicity; Effectiveness; Flow cytometry; Humans; IFI35; Immunodeficiency; Immunohistochemistry; Immunotherapy; Interferon regulatory factor 7; Laboratory animals; Lymphocytes; Lymphocytes T; Metastases; Mice; Microenvironments; Phosphatidylinositol 3-Kinases; Proteins; Proteomics; Proto-Oncogene Proteins c-akt - genetics; Signal Transduction; Stat1 protein; T cells; TOR protein; TOR Serine-Threonine Kinases - genetics; Toxicity; Tumor Microenvironment; Tumors; γ-Interferon; China; CD8+ T cells; IFI35; Immunotherapy; Colorectal cancer

A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for tumor-infiltrating cytotoxic T lymphocytes (CTL) in enhancing response to immunotherapy. Here, we aim to identify gene that induce proliferative and cytotoxic states of CD...