Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis

• Published in: Cancer letters Vol. 346; no. 1; pp. 6 - 16
• Main Author: Ji, Rui-Cheng
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.04.2014; Elsevier Limited
• Subjects: Angiogenesis; Animals; Breast cancer; Cell adhesion & migration; Cell growth; Cell Hypoxia - physiology; Chemokines; Hematology, Oncology and Palliative Medicine; HIF-1α; Humans; Hypoxia; Lymphangiogenesis; Lymphangiogenesis - physiology; Lymphatic endothelial cells; Lymphatic Metastasis - physiopathology; Lymphatic system; Permeability; Proteins; Rodents; Signal transduction; Transcription factors; Tumor metastasis; Tumor Microenvironment - physiology; Vascular endothelial growth factor; VEGF-A/-C/-D; Hypoxia; HIF-1α; Lymphatic endothelial cells; Lymphangiogenesis; VEGF-A/-C/-D; Tumor metastasis

Hypoxia and lymphangiogenesis are closely related processes that play a pivotal role in tumor invasion and metastasis. Intratumoral hypoxia is exacerbated as a result of oxygen consumption by rapidly proliferating tumor cells, insufficient blood supply and poor lymph drainage. Hypoxia induces functi...