Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

• Published in: Molecular cancer Vol. 22; no. 1; pp. 105 - 40
• Main Authors: Ye, Feng, Dewanjee, Saikat, Li, Yuehua, Jha, Niraj Kumar, Chen, Zhe-Sheng, Kumar, Ankush, Vishakha, Behl, Tapan, Jha, Saurabh Kumar, Tang, Hailin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.07.2023; BioMed Central; BMC
• Subjects: Angiogenesis; Breast cancer; Cancer; Cancer therapies; Cell cycle; Chemotherapy; Clinical aspects; Clinical trials; Combined Modality Therapy; Cyclin-dependent kinases; Development and progression; Disease management; DNA repair; Drug approval; Drug development; Drug therapy; Enzymes; Epidermal growth factor; Estrogens; Fatalities; FDA approval; Female; Fibroblasts; Growth factors; Health aspects; Humans; Immune checkpoint inhibitors; Immunosuppressive agents; Immunotherapy; Immunotherapy - methods; Ipilimumab; Kinases; Medical prognosis; Metastasis; Molecular biology; Molecular Targeted Therapy - methods; Monosaccharides; Patients; Phosphorylation; Proteins; Radiation therapy; Review; Sugars; Targeted therapies; Therapeutic targets; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - pathology; Vaccination; Targeted therapies; Clinical trials; Breast cancer; Immune-checkpoint Inhibitors; Immunotherapy

Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic management. However, recent advances in molecular biology and immunology enable to develop highly targeted therapies for many forms of breast cancer....