Identification of pyroptosis-related genes and potential drugs in diabetic nephropathy

• Published in: Journal of translational medicine Vol. 21; no. 1; pp. 490 - 17
• Main Authors: Yan, Meng, Li, Wenwen, Wei, Rui, Li, Shuwen, Liu, Yan, Huang, Yuqian, Zhang, Yunye, Lu, Zihao, Lu, Qian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.07.2023; BioMed Central; BMC
• Subjects: Analysis; Apoptosis; Care and treatment; Cell death; Clustering; Correlation analysis; Cytokines; Datasets; Diabetes; Diabetes mellitus; Diabetic nephropathies; Diabetic nephropathy; Diagnosis; Drug delivery; Drugs; Drug–gene prediction; Enrichment analysis; Gene expression; Genetic aspects; Genomes; Health aspects; Immune response; Immunosuppressive agents; Inflammation; Kidney diseases; Lasso regression; Microvasculature; Nephropathy; Oxidative stress; Pathogenesis; Prediction models; Protein-protein interactions; Pyroptosis; Regression analysis; Signal transduction; China; Diabetic nephropathy; Pyroptosis; Enrichment analysis; Lasso regression; Drug–gene prediction

Diabetic nephropathy (DN) is one of the serious microvascular complications of diabetes mellitus (DM). A growing body of research has demonstrated that the inflammatory state plays a critical role in the incidence and development of DN. Pyroptosis is a new way of programmed cell death, which has the...