Microcircuits and their interactions in epilepsy: is the focus out of focus?

• Published in: Nature neuroscience Vol. 18; no. 3; pp. 351 - 359
• Main Authors: Paz, Jeanne T, Huguenard, John R
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2015; Nature Publishing Group
• Subjects: 13; 13/51; 14; 14/35; 38; 631/378/1689/178; 631/378/3920; 692/308/1426; 82; 9/26; 9/30; 9/74; Animal Genetics and Genomics; Animals; Anticonvulsants; Behavioral Sciences; Biological Techniques; Biomedicine; Brain - pathology; Brain - physiopathology; Brain research; Convulsions & seizures; Drug therapy; Epilepsy; Epilepsy - pathology; Health aspects; Humans; Nerve Net - physiopathology; Neural networks; Neurobiology; Neurosciences; review-article; United States; United States > US; California

In this Review, Jeanne Paz and John Huguenard examine how recent work has informed us on the function of brain microcircuitry and how different circuit types may contribute to seizure generation and/or propagation. The authors also propose the idea that these microcircuits may regulate the spread of...