Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s disease

• Published in: Molecular neurodegeneration Vol. 18; no. 1; pp. 100 - 16
• Main Authors: Paul, Kimberly C., Zhang, Keren, Walker, Douglas I., Sinsheimer, Janet, Yu, Yu, Kusters, Cynthia, Del Rosario, Irish, Folle, Aline Duarte, Keener, Adrienne M., Bronstein, Jeff, Jones, Dean P., Ritz, Beate
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.12.2023; BioMed Central; BMC
• Subjects: Amino acids; Amino Acids - metabolism; Biliverdin; Chromatography; Cresol; Cysteine; Dopa; Glucuronides; Glutamine; Humans; Independent study; Inflammation; Levodopa; Lipid Metabolism; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolic networks; Metabolism; Metabolites; Metabolomics; Movement disorders; Neurodegenerative diseases; p-Cresol; Pantothenic acid; Parkinson Disease - metabolism; Parkinson's disease; Physiological aspects; Population studies; Quality control; Regression analysis; Sulfates; United States > US; California

Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways. Identify metabolic disturbances associated with Parkinson's disea...