Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation

• Published in: Arthritis research & therapy Vol. 25; no. 1; pp. 126 - 14
• Main Authors: Wang, Qingdong, Qiu, Hongbin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.07.2023; BioMed Central; BMC
• Subjects: Analysis; Animals; Antibodies; Arthritis; Arthritis, Gouty; Care and treatment; Cell culture; Cell cycle; Deubiquitinating Enzymes; Diagnosis; Drp1; Dynamins; Gout; Gouty arthritis; Health aspects; Inflammasomes; Macrophages; Mice; Microscopy; Mitochondrial Dynamics; Mitochondrial fission; NF-kappa B; NF-κB; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP3; Proteins; Reactive oxygen species; Reagents; Rheumatism; Statistical analysis; Testing; Uric acid metabolism; USP16; China; United States > US; NF-κB; NLRP3; USP16; Mitochondrial fission; Gouty arthritis; Drp1

Gouty arthritis is the most frequently diagnosed inflammatory arthritis worldwide. Dynamin-related protein 1 (Drp1), a regulator of mitochondrial fission, contributes to various inflammatory disorders via activating NLRP3 inflammasome. However, the biological role of Drp1 in gouty arthritis remains...