Ascorbic acid reduces Ropivacaine-induced myotoxicity in cultured human osteoporotic skeletal muscle cells

• Published in: BMC musculoskeletal disorders Vol. 24; no. 1; pp. 576 - 11
• Main Authors: Scioli, Maria Giovanna, Coniglione, Filadelfo, Greggi, Chiara, Evangelista, Luca, Fiorelli, Elena, Savino, Luca, Ferlosio, Amedeo, Piccirilli, Eleonora, Gasbarra, Elena, Iundusi, Riccardo, Tarantino, Umberto, Orlandi, Augusto
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.07.2023; BioMed Central; BMC
• Subjects: Analgesics; Anesthesia; Antibodies; Apoptosis; Ascorbic acid; Ascorbic Acid - metabolism; Ascorbic Acid - pharmacology; Autophagy; Biomechanics; Bone density; Bone mass; Bone surgery; Care and treatment; Cell Differentiation - physiology; Cell viability; Cells, Cultured; Complications and side effects; Cytotoxicity; Diagnosis; Dosage and administration; Experiments; Fractures; Gene expression; Health care; Hip; Humans; Joint surgery; Local anesthesia; Medical examination; Muscle Development - physiology; Muscle Fibers, Skeletal; Muscle, Skeletal - physiology; Muscles; Musculoskeletal diseases; Musculoskeletal system; Myoblasts; MyoD protein; Myogenesis; Myostatin; Myotoxicity; Myotoxicity - metabolism; Myotubes; Neuromuscular diseases; NOX4 protein; Osteoporosis; Oxidants; Oxidative stress; Pain; Patients; Propofol; Reactive Oxygen Species - metabolism; Recovery of function; Risk factors; Ropivacaine; Skeletal muscle; Vitamin C; Italy; United States > US; California; Oxidative stress; Myogenesis; Myotoxicity; Skeletal muscle; Local anesthesia

Osteoporosis is a worldwide health issue. Loss of bone mass is a potential risk factor for fragility fractures, and osteoporotic fractures place a considerable burden on society. Bone and muscle represent a functional unit in which the two tissues are intimately interconnected. Ropivacaine is a pote...