Ascorbic acid reduces Ropivacaine-induced myotoxicity in cultured human osteoporotic skeletal muscle cells - Scioli, Maria Giovanna; Coniglione, Filadelfo; Greggi, Chiara; Evangelista, Luca; Fiorelli, Elena; Savino, Luca; Ferlosio, Amedeo; Piccirilli, Eleonora; Gasbarra, Elena; Iundusi, Riccardo; Tarantino, Umberto; Orlandi, Augusto (BMC musculoskeletal disorders, 2023)
Keywords: Analgesics; Anesthesia; Antibodies; Apoptosis; Ascorbic acid; Ascorbic Acid - metabolism; Ascorbic Acid - pharmacology; Autophagy; Biomechanics; Bone density; Bone mass; Bone surgery; Care and treatment; Cell Differentiation - physiology; Cell viability; Cells, Cultured; Complications and side effects; Cytotoxicity; Diagnosis; Dosage and administration; Experiments; Fractures; Gene expression; Health care; Hip; Humans; Joint surgery; Local anesthesia; Medical examination; Muscle Development - physiology; Muscle Fibers, Skeletal; Muscle, Skeletal - physiology; Muscles; Musculoskeletal diseases; Musculoskeletal system; Myoblasts; MyoD protein; Myogenesis; Myostatin; Myotoxicity; Myotoxicity - metabolism; Myotubes; Neuromuscular diseases; NOX4 protein; Osteoporosis; Oxidants; Oxidative stress; Pain; Patients; Propofol; Reactive Oxygen Species - metabolism; Recovery of function; Risk factors; Ropivacaine; Skeletal muscle; Vitamin C; Italy; United States--US; California; Oxidative stress; Myogenesis; Myotoxicity; Skeletal muscle; Local anesthesia