Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro

• Published in: Frontiers in Pharmacology Vol. 14; p. 1186824
• Main Authors: Zou, Li-Li, Zhao, Fang-Ling, Qi, Yu-Ying, Wang, Shuang-Hu, Zhou, Quan, Geng, Pei-Wu, Zhou, Yun-Fang, Zhang, Qing, Chen, Hao, Dai, Da-Peng, Cai, Jian-Ping, Ji, Fu-Sui
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 23.05.2023; Frontiers Media S.A
• Subjects: allelic variant; catalytic activity; Chinese Han; CYP2J2; Pharmacology; polymorphism; RM1-950; Therapeutics. Pharmacology; CYP2J2; allelic variant; polymorphism; catalytic activity; Chinese Han

Genetic polymorphism of the cytochrome P450 (CYP) gene can significantly influence the metabolism of endogenous and xenobiotic compounds. However, few studies have focused on the polymorphism of CYP2J2 and its impact on drug catalytic activity, especially in the Chinese Han population. In this study...