The influence of intrathecal injection of methotrexate and dexamethasone on neuropsychiatric systemic lupus erythematosus (NPSLE): a retrospective cohort study of 386 patients with NPSLE

• Published in: Arthritis research & therapy Vol. 25; no. 1; pp. 50 - 14
• Main Authors: Nie, Yuxue, Sun, Boyuan, He, Xin, Zheng, Minmin, Wu, Di, Yang, Yunjiao, Zhang, Li, Bai, Wei, Jiang, Nan, Qiao, Lin, Huang, Can, Zhou, Shuang, Zhou, Jiaxin, Peng, Linyi, Niu, Jingwen, Li, Mengtao, Zhao, Yan, Zeng, Xiaofeng, Wang, Li, Zhang, Wen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.03.2023; BioMed Central; BMC
• Subjects: Adult; Arthritis; Blood; Care and treatment; Classification; Clinical outcomes; Cohort analysis; Dexamethasone; Diagnosis; Diagnostic tests; Disease; Dosage and administration; Female; Health aspects; Hospital patients; Hospitalization; Humans; Immunomodulators; Injections, Spinal; Laboratories; Lupus; Lupus erythematosus; Lupus Erythematosus, Systemic - complications; Lupus Vasculitis, Central Nervous System - complications; Lupus Vasculitis, Central Nervous System - drug therapy; Male; Medical records; Methotrexate; Methotrexate - therapeutic use; Nervous system; Neurologic manifestations; Patients; Recurrence; Retrospective Studies; Rheumatology; Steroids; Systemic; Systemic lupus erythematosus; Therapy; Young Adult; China; Therapy; Lupus erythematosus; Neurologic manifestations; Systemic

Neuropsychiatric involvement is one of the major concerns in systemic lupus erythematosus (SLE). The therapeutic effect of intrathecal treatment of methotrexate and dexamethasone has been investigated in some exploratory studies, but its influence on the long-term prognosis of neuropsychiatric SLE (...