Micro-Flow Visualization of Red Blood Cell-Enhanced Platelet Concentration at Sudden Expansion

• Published in: Annals of biomedical engineering Vol. 36; no. 7; pp. 1130 - 1141
• Main Authors: Zhao, Rui, Marhefka, Joie N., Shu, Fangjun, Hund, Samuel J., Kameneva, Marina V., Antaki, James F.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2008; Springer Nature B.V
• Subjects: Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Blood Cells - cytology; Blood Cells - physiology; Blood Platelets - cytology; Blood Platelets - physiology; Cell Culture Techniques - instrumentation; Cell Culture Techniques - methods; Classical Mechanics; Coculture Techniques - instrumentation; Coculture Techniques - methods; Equipment Design; Equipment Failure Analysis; Erythrocytes; Flow Cytometry - instrumentation; Flow Cytometry - methods; Humans; Image Interpretation, Computer-Assisted - instrumentation; Image Interpretation, Computer-Assisted - methods; Microfluidic Analytical Techniques - instrumentation; Microfluidic Analytical Techniques - methods; Microscopy, Fluorescence - instrumentation; Microscopy, Fluorescence - methods; Platelet Activation - physiology; Platelet margination; Red blood cell; Complex microflow; Artificial organs; Flow expansion; Thrombosis

Microscopic steps and crevices are inevitable features within prosthetic blood-contacting devices. This study aimed to elucidate the thrombogenicity of the associated microscopic flow features by studying the transport of fluorescent platelet-sized particles in a suspension of red blood cells (RBCs)...