Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

• Published in: British journal of psychiatry Vol. 195; no. 1; pp. 23 - 29
• Main Authors: Hamshere, M. L., Green, E. K., Jones, I. R., Jones, L., Moskvina, V., Kirov, G., Grozeva, D., Nikolov, I., Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Breen, G., Clair, D. St, Collier, D. A., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P., Holmans, P. A., Owen, M. J., O'Donovan, M. C., Craddock, N.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.07.2009; RCP; Royal College Of Psychiatrists
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bipolar affective disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - genetics; Case-Control Studies; Female; Genes; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Phenotypes; Polymorphism, Single Nucleotide - genetics; Psychiatric Status Rating Scales; Psychotic Disorders - diagnosis; Psychotic Disorders - genetics; Schizoaffective disorder; Serotonin Plasma Membrane Transport Proteins - genetics; Signals; Young Adult

Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic rese...