Changes in the innate immune response to SARS-CoV-2 with advancing age in humans

• Published in: Immunity & ageing Vol. 21; no. 1; pp. 21 - 15
• Main Authors: Agrawal, Sudhanshu, Tran, Michelle Thu, Jennings, Tara Sinta Kartika, Soliman, Marlaine Maged Hosny, Heo, Sally, Sasson, Bobby, Rahmatpanah, Farah, Agrawal, Anshu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.03.2024; BioMed Central; BMC
• Subjects: Age; Aging; Antibodies; Antiviral agents; Antiviral drugs; Blood & organ donations; Cardiovascular disease; CD4 antigen; CD8 antigen; Cell activation; COVID-19; Cytokines; Cytotoxicity; DCs; Dendritic cells; Diabetes; Gene expression; Health aspects; Homeostasis; Hospitalization; Hypertension; IL-29; Immune response; Infection; Infections; Inflammation; Innate immunity; Lymphocytes; Lymphocytes T; Macrophages; Monocytes; Mortality; Older people; Risk factors; RNA-seq; SARS-CoV-2; innate immunity; Scientific equipment and supplies industry; Severe acute respiratory syndrome coronavirus 2; Stains & staining; T cells; United States; Viral infections; Viruses; United States; United States > US; Monocytes; RNA-seq; DCs; IL-29; Aging; SARS-CoV-2; innate immunity; CD8 T cells

Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations and mortality. The recent COVID-19 pandemic has highlighted this as elderly subjects have emerged as vulnerable populations that display incre...