Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder

• Published in: Drug and alcohol dependence Vol. 221; p. 108614
• Main Authors: Angarita, Gustavo A., Matuskey, David, Pittman, Brian, Costeines, Jessica L., Potenza, Marc N., Jastreboff, Ania M., Schmidt, Heath D., Malison, Robert T.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2021; Elsevier Science Ltd
• Subjects: Addictive behaviors; Adult; Amylin; Cocaine; Cocaine - administration & dosage; Cocaine self-administration; Cocaine use disorder; Cocaine-Related Disorders - blood; Cocaine-Related Disorders - drug therapy; Cross-Over Studies; Double-Blind Method; Drug self-administration; Efficacy; Euphoria; Exenatide; Exenatide - pharmacology; Female; GLP-1; GLP-1 receptor agonists; Glucagon; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - blood; Glucagon-Like Peptide 1 - drug effects; Glucagon-Like Peptide-1 Receptor - agonists; Health services utilization; Help seeking behavior; Hormone levels; Humans; Incretins - pharmacology; Insulin; Insulin - blood; Islet Amyloid Polypeptide - blood; Islet Amyloid Polypeptide - drug effects; Male; Management; Middle Aged; Placebos; Pretreatment; Self Administration; Substance-related disorders; Tempering; Treatment Outcome; GLP-1; Cocaine use disorder; Substance-related disorders; Exenatide; Cocaine self-administration; Addictive behaviors

•The effects of a GLP-1 agonist (exenatide) on behavioral and subjective effects of cocaine were examined.•All subjects participated in a self-regulated cocaine self-administration paradigm.•Exenatide had no effect on administration and subjective effects of cocaine.•Both exenatide and cocaine decre...