Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive review

• Published in: Reproductive biology and endocrinology Vol. 21; no. 1; pp. 27 - 12
• Main Authors: Zhang, Wenying, Wu, Fuju
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.03.2023; BioMed Central; BMC
• Subjects: Adenosine triphosphate; Aging; Analysis; Assisted reproductive technology; Cell cycle; Cell division; Cell metabolism; Diabetes; Diabetes mellitus; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Embryogenesis; Embryos; Female; Fertility; Fertility - genetics; Fertilization; Genetic aspects; Haplotypes; Health aspects; Humans; Infertility; Infertility - genetics; Infertility, Female; Maternal inheritance; Metabolism; Mitochondria; Mitochondria - genetics; Mitochondria - pathology; Mitochondrial DNA; mtDNA; Mutation; Obesity; Oocytes; Oocytes - metabolism; Ovaries; Physiology; Pregnancy; Prevention; Quality management; Reproduction; Reproductive technologies; Respiration; Review; Risk factors; China; Obesity; Mitochondria; Reproduction; mtDNA; Aging; Assisted reproductive technology; Diabetes

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic development, and the genetic quality of future generations. One factor that is often ignored but is involved in the decline of oocyte quality is mitochondrial DNA (mtDNA) abnormalities. Abnormalities in mtDN...