Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs - Bradley, Sophie J.; Molloy, Colin; Valuskova, Paulina; Dwomoh, Louis; Scarpa, Miriam; Rossi, Mario; Finlayson, Lisa; Svensson, Kjell A.; Chernet, Eyassu; Barth, Vanessa N.; Gherbi, Karolina; Sykes, David A.; et al. (Nature chemical biology, 2020)
Keywords: 631/154; 631/154/436; 631/378/340; 631/92/96; Acetylcholine receptors (muscarinic); Acetylcholinesterase - metabolism; Alzheimer Disease - drug therapy; Alzheimer's disease; Animal models; Animals; Anxiety; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Cell Biology; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Cholinergic Agents - pharmacology; Cholinergics; Cholinesterase; Cholinesterase inhibitors; Cholinesterase Inhibitors - metabolism; Cholinesterase Inhibitors - pharmacology; Disease Models, Animal; Drug Design; Drug development; Epilepsy; Female; G protein-coupled receptors; Gene Knock-In Techniques; Ligands; Locomotion; Male; Mapping; Medical treatment; Mice; Mice, Inbred C57BL; Mutants; Neurodegenerative diseases; Phosphorylation; Proteins; Receptor, Muscarinic M1 - genetics; Receptor, Muscarinic M1 - metabolism; Receptors; Seizures; Side effects; Signaling; Therapeutic applications