Temporal Control of Metabolic Amplitude by Nocturnin

• Published in: Cell reports (Cambridge) Vol. 22; no. 5; pp. 1225 - 1235
• Main Authors: Stubblefield, Jeremy J., Gao, Peng, Kilaru, Gokhul, Mukadam, Bilal, Terrien, Jeremy, Green, Carla B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.01.2018; Elsevier
• Subjects: amplitude; Animals; cholesterol; Cholesterol - blood; circadian; Circadian Rhythm - physiology; deadenylation; Life Sciences; lipid; Lipid Metabolism - physiology; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; nocturnin; Nuclear Proteins - metabolism; obesity; poly(A); RNA, Messenger; Transcription Factors - metabolism; circadian; amplitude; cholesterol; poly(A); lipid; deadenylation; obesity; nocturnin

The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian...