The crucial role and mechanism of insulin resistance in metabolic disease

Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a system...

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Published inFrontiers in Endocrinology Vol. 14; p. 1149239
Main Authors Zhao, Xuefei, An, Xuedong, Yang, Cunqing, Sun, Wenjie, Ji, Hangyu, Lian, Fengmei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media SA 28.03.2023
Frontiers Media S.A
Subjects
Chronic Disease
Diseases of the endocrine glands. Clinical endocrinology
Endocrinology
Humans
Insulin Resistance
metabolic disease
Metabolic Diseases
Metabolic Diseases - metabolism
NAFLD
obesity
RC648-665
Receptor, Insulin
Receptor, Insulin - metabolism
Signal Transduction
T2DM
T2DM
NAFLD
metabolic disease
insulin resistance
obesity
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Abstract Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a systematic review of the causes, mechanisms, and treatments of IR. The pathogenesis of IR depends on genetics, obesity, age, disease, and drug effects. Mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of IR in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful. Based on the current understanding of IR mechanisms, there are still some vacancies to follow up and consider, and there is also a need to define more precise biomarkers for different chronic diseases and lifestyle interventions, and to explore natural or synthetic drugs targeting IR treatment. This could enable the treatment of patients with multiple combined metabolic diseases, with the aim of treating the disease holistically to reduce healthcare expenditures and to improve the quality of life of patients to some extent.
AbstractList Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a systematic review of the causes, mechanisms, and treatments of IR. The pathogenesis of IR depends on genetics, obesity, age, disease, and drug effects. Mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of IR in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful. Based on the current understanding of IR mechanisms, there are still some vacancies to follow up and consider, and there is also a need to define more precise biomarkers for different chronic diseases and lifestyle interventions, and to explore natural or synthetic drugs targeting IR treatment. This could enable the treatment of patients with multiple combined metabolic diseases, with the aim of treating the disease holistically to reduce healthcare expenditures and to improve the quality of life of patients to some extent.
Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a systematic review of the causes, mechanisms, and treatments of IR. The pathogenesis of IR depends on genetics, obesity, age, disease, and drug effects. Mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of IR in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful. Based on the current understanding of IR mechanisms, there are still some vacancies to follow up and consider, and there is also a need to define more precise biomarkers for different chronic diseases and lifestyle interventions, and to explore natural or synthetic drugs targeting IR treatment. This could enable the treatment of patients with multiple combined metabolic diseases, with the aim of treating the disease holistically to reduce healthcare expenditures and to improve the quality of life of patients to some extent.Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a systematic review of the causes, mechanisms, and treatments of IR. The pathogenesis of IR depends on genetics, obesity, age, disease, and drug effects. Mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of IR in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful. Based on the current understanding of IR mechanisms, there are still some vacancies to follow up and consider, and there is also a need to define more precise biomarkers for different chronic diseases and lifestyle interventions, and to explore natural or synthetic drugs targeting IR treatment. This could enable the treatment of patients with multiple combined metabolic diseases, with the aim of treating the disease holistically to reduce healthcare expenditures and to improve the quality of life of patients to some extent.
Author Hangyu Ji
Xuedong An
Cunqing Yang
Wenjie Sun
Xuefei Zhao
Fengmei Lian
AuthorAffiliation Guang’anmen Hospital, China Academy of Chinese Medical Sciences , Beijing , China
AuthorAffiliation_xml – name: Guang’anmen Hospital, China Academy of Chinese Medical Sciences , Beijing , China
Author_xml – sequence: 1
  givenname: Xuefei
  surname: Zhao
  fullname: Zhao, Xuefei
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  givenname: Xuedong
  surname: An
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– sequence: 4
  givenname: Wenjie
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  fullname: Ji, Hangyu
– sequence: 6
  givenname: Fengmei
  surname: Lian
  fullname: Lian, Fengmei
BackLink https://cir.nii.ac.jp/crid/1873118015553583488$$DView record in CiNii
https://www.ncbi.nlm.nih.gov/pubmed/37056675$$D View this record in MEDLINE/PubMed
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Keywords T2DM
NAFLD
metabolic disease
insulin resistance
obesity
Language English
License Copyright © 2023 Zhao, An, Yang, Sun, Ji and Lian.
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This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology
Reviewed by: Eric Hajduch, Institut National de la Santé et de la Recherche Médicale (INSERM), France; Xavier Prieur, INSERM U1087 Institut du Thorax, France
These authors share first authorship
Edited by: Jean-François Tanti, INSERM U1065 Centre Méditerranéen de Médecine Moléculaire, France
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Snippet Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and...
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pubmedcentral
proquest
pubmed
crossref
nii
SourceType Open Website
Open Access Repository
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StartPage 1149239
SubjectTerms Chronic Disease
Diseases of the endocrine glands. Clinical endocrinology
Endocrinology
Humans
Insulin Resistance
metabolic disease
Metabolic Diseases
Metabolic Diseases - metabolism
NAFLD
obesity
RC648-665
Receptor, Insulin
Receptor, Insulin - metabolism
Signal Transduction
T2DM
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Title The crucial role and mechanism of insulin resistance in metabolic disease
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https://www.ncbi.nlm.nih.gov/pubmed/37056675
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Volume 14
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