A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

• Published in: Current controlled trials in cardiovascular medicine Vol. 24; no. 1; pp. 213 - 22
• Main Authors: Haupenthal, Frederik, Rahn, Jette, Maggi, Fabrizio, Gelas, Fanny, Bourgeois, Philippe, Hugo, Christian, Jilma, Bernd, Böhmig, Georg A., Herkner, Harald, Wolzt, Michael, Doberer, Konstantin, Vossen, Matthias, Focosi, Daniele, Neuwirt, Hannes, Banas, Miriam, Banas, Bernhard, Budde, Klemens, Viklicky, Ondrej, Malvezzi, Paolo, Rostaing, Lionel, Rotmans, Joris I., Bakker, Stephan J. L., Eller, Kathrin, Cejka, Daniel, Pérez, Alberto Molina, Rodriguez-Arias, David, König, Franz, Bond, Gregor, Melzer, Georg, del Alamo, Martha, Beneyto, Isabel, Navarro, David, Ohlmann, Sophie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.03.2023; BioMed Central; BMC
• Subjects: Adult; Bacterial infections; Clinical trials; Cytomegalovirus; Dosage and administration; Drug dosages; Graft Rejection - diagnosis; Graft Rejection - prevention & control; Health aspects; Humans; Immunological monitoring; Immunosuppression; Immunosuppression Therapy; Immunosuppressive agents; Immunosuppressive Agents - adverse effects; Immunotherapy; Infections; Infectious diseases; Internal medicine; Kidney transplantation; Kidney Transplantation - adverse effects; Kidney transplants; Kidneys; Medicine; Nephrology; Organ transplant recipients; Patient outcomes; Patients; Personalised medicine; Precision medicine; Quality of Life; Severe acute respiratory syndrome coronavirus 2; Study Protocol; Tacrolimus; Tacrolimus - adverse effects; Torque teno virus; Transplantation; Austria; Czech Republic; Netherlands; France; Germany; Spain; Infection; Immunosuppression; Tacrolimus; Immunological monitoring; Torque teno virus; Personalised medicine; Graft rejection; Kidney transplantation

Immunosuppression after kidney transplantation is mainly guided via plasma tacrolimus trough level, which cannot sufficiently predict allograft rejection and infection. The plasma load of the non-pathogenic and highly prevalent torque teno virus (TTV) is associated with the immunosuppression of its...