Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 9; pp. 2204 - 2209
• Main Authors: Hashimoto, Kyoko, Ochi, Hiroki, Sunamura, Satoko, Kosaka, Nobuyoshi, Mabuchi, Yo, Fukuda, Toru, Yao, Kenta, Kanda, Hiroaki, Ae, Keisuke, Okawa, Atsushi, Akazawa, Chihiro, Ochiya, Takahiro, Futakuchi, Mitsuru, Takeda, Shu, Sato, Shingo
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.02.2018
• Subjects: Adenocarcinoma - metabolism; Animals; Biocompatibility; Biological Sciences; Biomedical materials; Biotechnology; Bone cancer; Bone Neoplasms - metabolism; Bone Neoplasms - secondary; Bone remodeling; Bone Substitutes; Bones; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell signaling; Differentiation (biology); Exosomes; Female; Genotype & phenotype; GTPase-Activating Proteins - genetics; GTPase-Activating Proteins - metabolism; Humans; Implantation; Lesions; Male; Mesenchymal Stromal Cells; Mesenchyme; Metastases; Metastasis; Mice; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Neoplasms, Experimental - metabolism; Osteoblastogenesis; Osteoblasts; Osteoclasts; Osteolysis; Phenotypes; Prostate cancer; Prostatic Neoplasms - metabolism; Stem cells; Tumor cell lines; Tumor cells; Tumors; bone microenvironment; prostate cancer; osteoblastic bone metastasis; exosome; cancer-secreted microRNA

Bone metastatic lesions are classified as osteoblastic or osteolytic lesions. Prostate and breast cancer patients frequently exhibit osteoblastic-type and osteolytic-type bone metastasis, respectively. In metastatic lesions, tumor cells interact with many different cell types, including osteoblasts,...