Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A - Hashimoto, Kyoko; Ochi, Hiroki; Sunamura, Satoko; Kosaka, Nobuyoshi; Mabuchi, Yo; Fukuda, Toru; Yao, Kenta; Kanda, Hiroaki; Ae, Keisuke; Okawa, Atsushi; Akazawa, Chihiro; Ochiya, Takahiro; et al. (Proceedings of the National Academy of Sciences - PNAS, 2018)
Keywords: Adenocarcinoma - metabolism; Animals; Biocompatibility; Biological Sciences; Biomedical materials; Biotechnology; Bone cancer; Bone Neoplasms - metabolism; Bone Neoplasms - secondary; Bone remodeling; Bone Substitutes; Bones; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell signaling; Differentiation (biology); Exosomes; Female; Genotype & phenotype; GTPase-Activating Proteins - genetics; GTPase-Activating Proteins - metabolism; Humans; Implantation; Lesions; Male; Mesenchymal Stromal Cells; Mesenchyme; Metastases; Metastasis; Mice; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Neoplasms, Experimental - metabolism; Osteoblastogenesis; Osteoblasts; Osteoclasts; Osteolysis; Phenotypes; Prostate cancer; Prostatic Neoplasms - metabolism; Stem cells; Tumor cell lines; Tumor cells; Tumors; bone microenvironment; prostate cancer; osteoblastic bone metastasis; exosome; cancer-secreted microRNA