Ferroptosis-related genes, a novel therapeutic target for focal segmental glomerulosclerosis

• Published in: BMC nephrology Vol. 25; no. 1; pp. 58 - 12
• Main Authors: Lin, Yanbin, He, Jinxuan, Mou, Zhixiang, Chen, Huiting, You, Wenkang, Guan, Tianjun, Chen, Lan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.02.2024; BioMed Central; BMC
• Subjects: Activating transcription factor 3; Apoptosis; Bioinformatics; Care and treatment; Cell death; Circular RNA; Datasets; Drug delivery; Drug development; Ferroptosis; Ferroptosis - genetics; Focal segmental glomerulosclerosis (FSGS); Gene expression; Genes; Genes, vif; Genetic aspects; Genomes; Glomerulonephritis; Glomerulosclerosis, Focal Segmental - genetics; Glomerulosclerosis, Focal Segmental - therapy; Health aspects; Humans; Kidney cancer; Kidney Tubules; Kidneys; Lipid peroxidation; Lipids; Metabolic pathways; MicroRNAs; MicroRNAs - genetics; miRNA; Mitophagy; Morphology; Ontology; Proteins; Renal cell carcinoma; Renal tubule; Renal tubules; Reproducibility; RNA, Circular; RNA, Messenger; Software; Steroids; Therapeutic targets; Transcriptomics; China; Ferroptosis; Renal tubule; Bioinformatics; Focal segmental glomerulosclerosis (FSGS)

Recent studies have suggested that ferroptosis participates in various renal diseases. However, its effect on focal segmental glomerulosclerosis remains unclear. This study analyzed the GSE125779 and GSE121211 datasets to identify the differentially expressed genes (DEGs) in renal tubular samples wi...