A pragmatic, open-label, multi-center, randomized controlled clinical trial on the rotational use of interfaces vs standard of care in patients treated with noninvasive positive pressure ventilation for acute hypercapnic respiratory failure: the ROTAtional-USE of interface STUDY (ROTA-USE STUDY)

• Published in: Current controlled trials in cardiovascular medicine Vol. 24; no. 1; pp. 527 - 14
• Main Authors: Vaschetto, Rosanna, Gregoretti, Cesare, Scotti, Lorenza, De Vita, Nello, Carlucci, Annalisa, Cortegiani, Andrea, Crimi, Claudia, Mattei, Alessio, Scala, Raffaele, Rocca, Eduardo, Longhini, Federico, Cammarota, Gianmaria, Misseri, Giovanni, Dal Molin, Alberto, Scolletta, Sabino, Nava, Stefano, Maggiore, Salvatore Maurizio, Navalesi, Paolo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.08.2023; BioMed Central; BMC
• Subjects: Adult; Airway management; Care and treatment; Chronic obstructive pulmonary disease; Clinical trials; Complications and side effects; Continuous positive airway pressure; Critical care; Extubation; Hospital costs; Humans; Hypercapnic acute respiratory failure; Intensive care; Interfaces; Internal medicine; Intubation; Medical care; Medicine; Noninvasive ventilation; Noninvasive Ventilation - adverse effects; Noninvasive Ventilation - methods; Ostomy; Patient outcomes; Patients; Positive-Pressure Respiration - adverse effects; Positive-Pressure Respiration - methods; Pressure Ulcer - epidemiology; Pressure Ulcer - prevention & control; Pressure ulcers; Quality management; Research design; Respiratory failure; Respiratory insufficiency; Respiratory Insufficiency - therapy; Rotational use of interfaces; Standard of Care; Study Protocol; Treatment Outcome; Ventilators; Italy; Noninvasive ventilation; Pressure ulcers; Hypercapnic acute respiratory failure; Rotational use of interfaces

In the last decades, noninvasive ventilation (NIV) has been increasingly used to support patients with hypercapnic and hypoxemic acute respiratory failure. Pressure ulcers are a frequently observed NIV-related adverse effect, directly related to interface type and exposure time. Switching to a diffe...