Asporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms - Wang, Lili; Wu, Huanwen; Wang, Li; Zhang, Hui; Lu, Junliang; Liang, Zhiyong; Liu, Tonghua (Cancer letters, 2017)
Keywords: Aged; AKT protein; Asporin; Autocrine Communication; Autocrine signalling; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biotechnology; Breast cancer; CD44 antigen; Cell Line, Tumor; Cell Proliferation; EMT; Epithelial-Mesenchymal Transition; Extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Fibroblasts; Gene expression; Hematology, Oncology and Palliative Medicine; Humans; Hyaluronan Receptors - metabolism; Invasion; Kinases; Male; Mesenchyme; Metabolic pathways; Metastasis; Middle Aged; Migration; Neoplasm Invasiveness; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pancreatic Stellate Cells - metabolism; Pancreatic Stellate Cells - pathology; Paracrine Communication; Paracrine signalling; Penicillin; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt - metabolism; RNA Interference; Signal Transduction; Stellate cells; Stroma; Stromal Cells - metabolism; Stromal Cells - pathology; Transcription Factor RelA - metabolism; Transfection; Tumor Microenvironment; United States--US; Migration; MMPs; CM; TMAs; EMT; Invasion; ECM; PCC; ASC; SLRP; α-SMA; PDAC; CAFs; Asporin; Pancreatic cancer; PSCs; ATRA; conditioned medium; α-smooth muscle actin; pancreatic ductal adenocarcinoma; Tissue microarrays; matrix metalloproteinases; pancreatic stellate cells; all-trans retinoic acid; pancreatic cancer cell; cancer-associated fibroblasts; the American Cancer Society; small leucine-rich proteoglycan; extracellular matrix