AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells

• Published in: Respiratory research Vol. 24; no. 1; pp. 185 - 15
• Main Authors: Becker, Jr, Eugene, Husain, Maroof, Bone, Nathaniel, Smith, Samuel, Morris, Peter, Zmijewski, Jaroslaw W
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.07.2023; BioMed Central; BMC
• Subjects: Accumulation; Alveolar Epithelial Cells; Alveoli; AMP-activated protein kinase; AMP-Activated Protein Kinases; Analysis; Animal models; Animals; Antibodies; Apoptosis; Bacteria; Bacterial diseases; Bacterial infections; Bacterial pneumonia; Bioenergetics; Bronchopulmonary infection; Complications and side effects; Cytokines; Efferocytosis; Endoplasmic reticulum; Epithelial cells; Epithelium; Flow cytometry; Glycogen Synthase Kinase 3 beta; Health aspects; Hospitals; Inactivation; Injury prevention; Intensive care units; Kinases; Laboratories; Leukocytes (neutrophilic); Lung Injury - drug therapy; Lungs; Macrophages; Metabolism; Metformin; Mice; Mitochondria; Mortality; Nitric oxide; Nosocomial infections; Pathogens; Phosphates; Phosphorylation; Pneumonia; Prevention; Protein kinases; Proteins; Recovery; Risk factors; Sepsis; Statistical significance; Stress; Therapeutic applications; United Kingdom; Minneapolis Minnesota; United States > US; Efferocytosis; Mitochondria; Pneumonia; Bacterial infections; Endoplasmic reticulum; Alveolar epithelial cells

Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious and prolonged respiratory complications among survivors. Given that endoplasmic reticulum (ER) stress is a hallmark of sepsis-related alveolar epithelial cell...