Pretreatment Dynamic Susceptibility Contrast MRI Perfusion in Glioblastoma: Prediction of EGFR Gene Amplification

• Published in: Clinical neuroradiology (Munich) Vol. 25; no. 2; pp. 143 - 150
• Main Authors: Gupta, A., Young, R. J., Shah, A. D., Schweitzer, A. D., Graber, J. J., Shi, W., Zhang, Z., Huse, J., Omuro, A. M. P.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2015; Springer; Springer Nature B.V
• Subjects: Blood Volume - physiology; Brain cancer; Brain Neoplasms - blood supply; Brain Neoplasms - genetics; Brain Neoplasms - surgery; Cohort Studies; Contrast Media; DNA Mutational Analysis; Female; Gene amplification; Gene Amplification - genetics; Gene Expression Regulation, Neoplastic - genetics; Gene mutations; Genes; Genetic aspects; Genetic screening; Glioblastoma - blood supply; Glioblastoma - genetics; Glioblastoma - surgery; Glioblastoma multiforme; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Mutation; Neurology; Neuroradiology; Neurosurgery; NMR; Nuclear magnetic resonance; Occipital Lobe - blood supply; Occipital Lobe - pathology; Occipital Lobe - surgery; Original Article; Receptor, Epidermal Growth Factor - genetics; Retrospective Studies; Statistics as Topic; Dynamic susceptibility contrast; Gene; MRI; Perfusion; EGFR; Glioblastoma

Background and Purpose Molecular and genetic testing is becoming increasingly relevant in GBM. We sought to determine whether dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion imaging could predict EGFR-defined subtypes of GBM. Materials and Methods We retrospectively...