Molecular mechanisms of tumor resistance to radiotherapy

• Published in: Molecular cancer Vol. 22; no. 1; pp. 96 - 21
• Main Authors: Wu, Yu, Song, Yingqiu, Wang, Runze, Wang, Tianlu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.06.2023; BioMed Central; BMC
• Subjects: Apoptosis; Breast; Cancer; Cancer therapies; Care and treatment; Cell cycle; Chemotherapy; Colorectal cancer; DNA damage; DNA repair; Esophageal cancer; Ferroptosis; Glioblastoma; Gliomas; Health aspects; Humans; Immunotherapy; Kinases; Medical prognosis; Microenvironments; Molecular modelling; Mortality; Neoplasm Recurrence, Local; Proteins; Radiation; Radiation therapy; Radiotherapy; Review; RNA; RNA polymerase; Solid tumors; Stem cells; Treatment Outcome; Tumor Microenvironment; Tumor resistance; Tumors; Radiotherapy; Tumor resistance; Cancer

Cancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma. Resistance to radiation can lead to local treatment failure and even cancer recurrence. In thi...