Kinetics of imidazole propionate from orally delivered histidine in mice and humans

• Published in: NPJ biofilms and microbiomes Vol. 10; no. 1; pp. 118 - 12
• Main Authors: Warmbrunn, Moritz V., Attaye, Ilias, Horak, Anthony, Banerjee, Rakhee, Massey, William J., Varadharajan, Venkateshwari, Rampanelli, Elena, Hao, Youling, Dutta, Sumita, Nemet, Ina, Aron-Wisnewsky, Judith, Clément, Karine, Koopen, Annefleur, Wortelboer, Koen, Bergh, Per-Olof, Davids, Mark, Mohamed, Nadia, Kemper, E. Marleen, Hazen, Stanley, Groen, Albert K., van Raalte, Daniel H., Herrema, Hilde, Backhed, Fredrik, Brown, J. Mark, Nieuwdorp, Max
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.11.2024; Nature Publishing Group; [London?]: Springer Nature published in partnership with Nanyang Technological University; Nature Portfolio
• Subjects: 631/326/107; 692/700; Administration, Oral; Adult; Amino acids; Animal models; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Antibiotics; Antifungal agents; Bacteria - classification; Bacteria - drug effects; Bacteria - genetics; Bacteria - metabolism; Biofilms; Biomedical and Life Sciences; Body fat; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diet; Diet, High-Fat; Dietary Supplements; Drug dosages; Female; Food; Gastrointestinal Microbiome - drug effects; High fat diet; Histidine; Histidine - metabolism; Humans; Imidazole; Imidazoles - administration & dosage; Imidazoles - metabolism; Imidazoles - pharmacology; Insulin; Intestinal microflora; Kinetics; Life Sciences; Male; Medical Biotechnology (Focus on Cell Biology (incl. Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy); Medical Microbiology; Medicinsk bioteknologi (Inriktn. mot cellbiologi (inkl. stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci); Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Microbial Ecology; Microbial Genetics and Genomics; Microbiology; Microbiota; Microorganisms; Middle Aged; Nutrition research; Physiology; Propionic acid; Skin

Imidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated in type 2 diabetes (T2D). However, the source of histidine and the role of the gut microbiota remain unclear. We conducted an intervention study in mice and humans, comparing ImP ki...