Segregating two inhibitory circuits in human motor cortex at the level of GABAA receptor subtypes: A TMS study

• Published in: Clinical neurophysiology Vol. 118; no. 10; pp. 2207 - 2214
• Main Authors: Di Lazzaro, V., Pilato, F., Dileone, M., Profice, P., Ranieri, F., Ricci, V., Bria, P., Tonali, P.A., Ziemann, U.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.10.2007; Elsevier Science
• Subjects: Adult; Benzodiazepines; Biological and medical sciences; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Cross-Over Studies; Diazepam - pharmacology; Electrodiagnosis. Electric activity recording; Evoked Potentials, Motor - drug effects; GABA Agonists - pharmacology; GABA Modulators - pharmacology; Humans; Hypnotics and Sedatives - pharmacology; Hypnotics. Sedatives; Investigative techniques, diagnostic techniques (general aspects); Lorazepam - pharmacology; Medical sciences; Motor Cortex - physiology; Nervous system; Neurology; Neurons, Afferent - drug effects; Neuropharmacology; Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Pyridines - pharmacology; Receptors, GABA-A - drug effects; Receptors, GABA-A - physiology; Short interval intracortical inhibition; Short latency afferent inhibition; Transcranial Magnetic Stimulation; Short latency afferent inhibition; Transcranial magnetic stimulation; Short interval intracortical inhibition; Benzodiazepines; Human; Modification; Motor pathway; Evaluation scale; Visual analogue scale; Central nervous system; Subunit; Encephalon; Motor cortex; Zolpidem; Lorazepam; Sedative; Gabaergic receptor A; Subtype; Diazepam; Biological receptor

To investigate if different interneuronal circuits in human motor cortex mediate inhibition through different subtypes of the gamma-aminobutyric acid A receptor (GABAAR). Two distinct forms of motor cortical inhibition were measured in 10 healthy subjects by established transcranial magnetic stimula...