Left Ventricular Deformation and Myocardial Fibrosis in Patients With Advanced Heart Failure Requiring Transplantation

• Published in: Journal of cardiac failure Vol. 22; no. 11; pp. 901 - 907
• Main Authors: Cameli, Matteo, Mondillo, Sergio, Righini, Francesca Maria, Lisi, Matteo, Dokollari, Aleksander, Lindqvist, Per, Maccherini, Massimo, Henein, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016
• Subjects: Advanced cardiac failure; Aged; Biopsy, Needle; Cardiovascular; Cohort Studies; Comorbidity; Databases, Factual; echocardiography; Echocardiography - methods; Female; Fibrosis - diagnostic imaging; Fibrosis - epidemiology; Fibrosis - pathology; Fibrosis - surgery; Heart Failure - diagnostic imaging; Heart Failure - epidemiology; Heart Failure - surgery; heart transplantation; Heart Transplantation - methods; Heart Transplantation - mortality; Hospital Mortality; Humans; Image Interpretation, Computer-Assisted; Immunohistochemistry; Italy; LV fibrosis; LV strain; Male; Middle Aged; Myocardium - pathology; Patient Selection; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; ROC Curve; Severity of Illness Index; speckle tracking; Stroke Volume - physiology; Survival Analysis; Treatment Outcome; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - epidemiology; Ventricular Dysfunction, Left - pathology; Ventricular Dysfunction, Left - surgery; speckle tracking; LV strain; Advanced cardiac failure; heart transplantation; LV fibrosis; echocardiography; advanced cardiac failure

•Patients with extensive fibrosis had worse left ventricular (LV) global longitudinal strain (GLS) and global circumferential strain compared with those with less fibrosis.•LV myocardial fibrosis strongly correlated with GLS but did not correlate with LV ejection fraction.•GLS is the most accurate L...