A causal relationship between panic disorder and risk of alzheimer disease: a two-sample mendelian randomization analysis

• Published in: BMC psychiatry Vol. 24; no. 1; pp. 178 - 10
• Main Authors: Tian, Yueqin, Ye, Qiuping, Qiao, Jia, Wang, Lian, Dai, Yong, Wen, Hongmei, Dou, Zulin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.03.2024; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer Disease; Alzheimer Disease - genetics; Alzheimer's disease; Analysis; Analysis of Variance; Anxiety; Care and treatment; Causal inference; Causality; Comorbidity; Complications and side effects; Confounding (Statistics); Datasets; Dementia; Diagnosis; Drug development; Genetic susceptibility; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Humans; Hypotheses; Medical research; Medicine, Experimental; Memory; Mendelian Randomization Analysis; Observational studies; Panic attacks; Panic disorder; Panic Disorder - genetics; Panic disorders; Pleiotropy; Population; Risk factors; Sensitivity analysis; China; Mendelian randomization analysis; Genome-wide Association study; Alzheimer Disease; Causality; Panic disorder

Observational studies have suggested a link between panic disorder (PD) and Alzheimer disease (AD). This study aimed to identify the underlying association of PD with the risk of AD using Mendelian randomization. Genetic instrumental variables (IVs) were retrieved in the genome-wide association stud...