A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice

• Published in: Journal of neuroinflammation Vol. 21; no. 1; p. 14
• Main Authors: Baker, Tamara L, Wright, David K, Uboldi, Alessandro D, Tonkin, Christopher J, Vo, Anh, Wilson, Trevor, McDonald, Stuart J, Mychasiuk, Richelle, Semple, Bridgette D, Sun, Mujun, Shultz, Sandy R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2024; BioMed Central; BMC
• Subjects: Analysis; Animals; Brain; Brain damage; Brain Injuries - complications; Brain Injuries, Traumatic - complications; Brain research; Bupivacaine; Care and treatment; Cats; Central nervous system; Chronic infection; Complications and side effects; Craniotomy; Custom design; Diagnosis; Excitotoxicity; Female; Females; Food contamination & poisoning; Gene expression; Glutamatergic transmission; Humans; Immune response; Infection; Infections; Inflammation; Injuries; Magnetic resonance imaging; Male; Males; Medical research; Mice; Morbidity; Mortality; Neuroinflammation; Neuroinflammatory Diseases; Neurotoxicity; Oxidative stress; Protozoa; Risk factors; Sex; Spleen; Substantia alba; Toxoplasma gondii; Toxoplasmosis; Toxoplasmosis - complications; Traumatic brain injury; Canada; United States > US; Oxidative stress; Immune response; MRI; Excitotoxicity; Sex; Neuroinflammation; Behavior; Females

Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that one-third of the human population is incurably infected with...