Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia

• Published in: Schizophrenia research Vol. 100; no. 1; pp. 120 - 132
• Main Authors: Zhou, Yuan, Shu, Ni, Liu, Yong, Song, Ming, Hao, Yihui, Liu, Haihong, Yu, Chunshui, Liu, Zhening, Jiang, Tianzi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.2008; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Anatomical connectivity; Anisotropy; Biological and medical sciences; Brain Mapping; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Control Groups; Diffusion Magnetic Resonance Imaging - statistics & numerical data; Diffusion tensor tractography; Female; fMRI; Functional connectivity; Functional Laterality - physiology; Hippocampus; Hippocampus - pathology; Hippocampus - physiopathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical sciences; Neural Pathways - pathology; Neural Pathways - physiopathology; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Rest - physiology; Schizophrenia; Schizophrenia - pathology; Schizophrenia - physiopathology; Functional connectivity; MPFC; STG; Schizophrenia; fMRI; PCC; DT-t; Anatomical connectivity; DTI; BOLD; FA; Diffusion tensor tractography; Hippocampus; medial prefrontal cortex; blood oxygen level-dependent; diffusion tensor tractography; posterior cingulate cortex; diffusion tensor imaging; fractional anisotropy; functional magnetic resonance imaging; superior temporal gyrus; Human; Tractography; Central nervous system; Metabolism; Nuclear magnetic resonance imaging; Encephalon; Psychosis; Rest; Diffusion tensor; Medical imagery; Functional imaging

Hippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imagin...