Transferring and generalizing deep-learning-based neural encoding models across subjects

• Published in: NeuroImage (Orlando, Fla.) Vol. 176; pp. 152 - 163
• Main Authors: Wen, Haiguang, Shi, Junxing, Chen, Wei, Liu, Zhongming
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2018; Elsevier Limited
• Subjects: Accuracy; Adult; Bayes Theorem; Bayesian analysis; Bayesian inference; Brain; Brain - physiology; Brain mapping; Brain Mapping - methods; Cortex; Datasets; Deep Learning; Distance learning; Female; Functional magnetic resonance imaging; Humans; Incremental learning; Information processing; Magnetic Resonance Imaging; Mathematical models; Natural vision; Neural coding; Neural encoding; Neural networks; Neural Pathways - physiology; Neuroimaging; Pattern Recognition, Visual - physiology; Population studies; Reproducibility of Results; Visual stimuli; Young Adult; Natural vision; Deep learning; Incremental learning; Bayesian inference; Neural encoding
• DOI: 10.1016/j.neuroimage.2018.04.053
• ISSN: 1053-8119; 1095-9572

Recent studies have shown the value of using deep learning models for mapping and characterizing how the brain represents and organizes information for natural vision. However, modeling the relationship between deep learning models and the brain (or encoding models), requires measuring cortical responses to large and diverse sets of natural visual stimuli from single subjects. This requirement limits prior studies to few subjects, making it difficult to generalize findings across subjects or for a population. In this study, we developed new methods to transfer and generalize encoding models across subjects. To train encoding models specific to a target subject, the models trained for other subjects were used as the prior models and were refined efficiently using Bayesian inference with a limited amount of data from the target subject. To train encoding models for a population, the models were progressively trained and updated with incremental data from different subjects. For the proof of principle, we applied these methods to functional magnetic resonance imaging (fMRI) data from three subjects watching tens of hours of naturalistic videos, while a deep residual neural network driven by image recognition was used to model visual cortical processing. Results demonstrate that the methods developed herein provide an efficient and effective strategy to establish both subject-specific and population-wide predictive models of cortical representations of high-dimensional and hierarchical visual features.