Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I: HPA axis responses

• Published in: The international journal of neuropsychopharmacology Vol. 11; no. 3; pp. 365 - 372
• Main Authors: Shalev, Arieh Y., Videlock, Elizabeth J., Peleg, Tamar, Segman, Ronen, Pitman, Roger K., Yehuda, Rachel
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.05.2008; Oxford University Press
• Subjects: Accidents, Traffic; Adrenocorticotropic Hormone - metabolism; Adult; Corticotropin-Releasing Hormone; Female; Hormones; Hormones - metabolism; Humans; Hydrocortisone - metabolism; Hypothalamo-Hypophyseal System - metabolism; Longitudinal Studies; Male; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System - metabolism; Post traumatic stress disorder; Receptors, Glucocorticoid - metabolism; Saliva - metabolism; Stress Disorders, Post-Traumatic - etiology; Stress Disorders, Post-Traumatic - metabolism; Stress Disorders, Post-Traumatic - pathology; Terrorism; Time Factors; Trauma Severity Indices; ACTH; cortisol; post-traumatic stress disorder; glucocorticoid receptors; HPA axis; stress hormones

The aim of the study was to evaluate the association between post-traumatic disorder (PTSD) and hypothalamic–pituitary–adrenal (HPA) axis responses to the triggering trauma. A companion paper evaluates the adrenergic response and interactions between the two. We measured plasma and saliva cortisol,...