Exosomes in liver fibrosis: The role of modulating hepatic stellate cells and immune cells, and prospects for clinical applications

• Published in: Frontiers in Immunology Vol. 14; p. 1133297
• Main Authors: Liu, Yufei, Zheng, Yuhong, Yang, Yang, Liu, Ke, Wu, Jianying, Gao, Peiyang, Zhang, Chuantao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 20.03.2023; Frontiers Media S.A
• Subjects: Cell Communication; clinical application; exosome; Exosomes; Exosomes - metabolism; hepatic stellate cell; Hepatic Stellate Cells; Hepatic Stellate Cells - metabolism; Hepatocytes; Hepatocytes - metabolism; Humans; immune cell; Immunologic diseases. Allergy; Immunology; Liver Cirrhosis; Liver Cirrhosis - pathology; liver fibrosis; RC581-607; immune cell; clinical application; liver fibrosis; hepatic stellate cell; exosome

Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation into myofibroblasts. Complex multidirectional int...