Exosomes in liver fibrosis: The role of modulating hepatic stellate cells and immune cells, and prospects for clinical applications

Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation into myofibroblasts. Complex multidirectional int...

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Published inFrontiers in Immunology Vol. 14; p. 1133297
Main Authors Liu, Yufei, Zheng, Yuhong, Yang, Yang, Liu, Ke, Wu, Jianying, Gao, Peiyang, Zhang, Chuantao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media SA 20.03.2023
Frontiers Media S.A
Subjects
Cell Communication
clinical application
exosome
Exosomes
Exosomes - metabolism
hepatic stellate cell
Hepatic Stellate Cells
Hepatic Stellate Cells - metabolism
Hepatocytes
Hepatocytes - metabolism
Humans
immune cell
Immunologic diseases. Allergy
Immunology
Liver Cirrhosis
Liver Cirrhosis - pathology
liver fibrosis
RC581-607
immune cell
clinical application
liver fibrosis
hepatic stellate cell
exosome
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Abstract Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation into myofibroblasts. Complex multidirectional interactions between HSCs, immune cells, and cytokines are also critical for the progression of liver fibrosis. Despite the advances in treatments for liver fibrosis, they do not meet the current medical needs. Exosomes are extracellular vesicles of 30-150 nm in diameter and are capable of intercellular transport of molecules such as lipids, proteins and nucleic acids. As an essential mediator of intercellular communication, exosomes are involved in the physiological and pathological processes of many diseases. In liver fibrosis, exosomes are involved in the pathogenesis mainly by regulating the activation of HSCs and the interaction between HSCs and immune cells. Serum-derived exosomes are promising biomarkers of liver fibrosis. Exosomes also have promising therapeutic potential in liver fibrosis. Exosomes derived from mesenchymal stem cells and other cells exhibit anti-liver fibrosis effects. Moreover, exosomes may serve as potential therapeutic targets for liver fibrosis and hold promise in becoming drug carriers for liver fibrosis treatment.
AbstractList Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation into myofibroblasts. Complex multidirectional interactions between HSCs, immune cells, and cytokines are also critical for the progression of liver fibrosis. Despite the advances in treatments for liver fibrosis, they do not meet the current medical needs. Exosomes are extracellular vesicles of 30-150 nm in diameter and are capable of intercellular transport of molecules such as lipids, proteins and nucleic acids. As an essential mediator of intercellular communication, exosomes are involved in the physiological and pathological processes of many diseases. In liver fibrosis, exosomes are involved in the pathogenesis mainly by regulating the activation of HSCs and the interaction between HSCs and immune cells. Serum-derived exosomes are promising biomarkers of liver fibrosis. Exosomes also have promising therapeutic potential in liver fibrosis. Exosomes derived from mesenchymal stem cells and other cells exhibit anti-liver fibrosis effects. Moreover, exosomes may serve as potential therapeutic targets for liver fibrosis and hold promise in becoming drug carriers for liver fibrosis treatment.
Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation into myofibroblasts. Complex multidirectional interactions between HSCs, immune cells, and cytokines are also critical for the progression of liver fibrosis. Despite the advances in treatments for liver fibrosis, they do not meet the current medical needs. Exosomes are extracellular vesicles of 30-150 nm in diameter and are capable of intercellular transport of molecules such as lipids, proteins and nucleic acids. As an essential mediator of intercellular communication, exosomes are involved in the physiological and pathological processes of many diseases. In liver fibrosis, exosomes are involved in the pathogenesis mainly by regulating the activation of HSCs and the interaction between HSCs and immune cells. Serum-derived exosomes are promising biomarkers of liver fibrosis. Exosomes also have promising therapeutic potential in liver fibrosis. Exosomes derived from mesenchymal stem cells and other cells exhibit anti-liver fibrosis effects. Moreover, exosomes may serve as potential therapeutic targets for liver fibrosis and hold promise in becoming drug carriers for liver fibrosis treatment.Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation into myofibroblasts. Complex multidirectional interactions between HSCs, immune cells, and cytokines are also critical for the progression of liver fibrosis. Despite the advances in treatments for liver fibrosis, they do not meet the current medical needs. Exosomes are extracellular vesicles of 30-150 nm in diameter and are capable of intercellular transport of molecules such as lipids, proteins and nucleic acids. As an essential mediator of intercellular communication, exosomes are involved in the physiological and pathological processes of many diseases. In liver fibrosis, exosomes are involved in the pathogenesis mainly by regulating the activation of HSCs and the interaction between HSCs and immune cells. Serum-derived exosomes are promising biomarkers of liver fibrosis. Exosomes also have promising therapeutic potential in liver fibrosis. Exosomes derived from mesenchymal stem cells and other cells exhibit anti-liver fibrosis effects. Moreover, exosomes may serve as potential therapeutic targets for liver fibrosis and hold promise in becoming drug carriers for liver fibrosis treatment.
Author Yuhong Zheng
Chuantao Zhang
Yufei Liu
Peiyang Gao
Ke Liu
Yang Yang
Jianying Wu
AuthorAffiliation 2 Department of Digestive Medicine, Hospital of Chengdu University of Traditional Chinese Medicine , Chengdu , China
3 Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine , Chengdu , China
1 Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine , Chengdu , China
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– name: 3 Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine , Chengdu , China
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Cites_doi 10.1016/j.addr.2020.06.026
10.1039/d1bm01663f
10.1186/s12951-021-01138-2
10.1080/10717544.2022.2030428
10.1128/JVI.02225-16
10.3390/mi12121563
10.1096/fj.201802675R
10.21037/atm-20-7787
10.1080/10717544.2020.1850917
10.3389/fimmu.2022.833878
10.3748/wjg.v27.i14.1419
10.1002/hep.28644
10.4161/onci.20897
10.3389/fimmu.2022.860807
10.1038/s41419-022-04764-2
10.31083/j.fbl2703104
10.1016/j.yexcr.2021.112663
10.3389/fphar.2021.677810
10.1096/fj.202002777RR
10.1002/hep4.1721
10.1007/s12072-017-9808-z
10.5152/tjg.2018.17330
10.1152/physrev.00013.2007
10.1002/hep.30698
10.1111/jcmm.16935
10.3748/wjg.v21.i41.11567
10.3389/fcell.2021.730176
10.3389/fgene.2021.673286
10.1016/j.omtn.2021.10.022
10.1111/jcmm.13170
10.2174/1381612821666151027153410
10.1155/2018/6079642
10.1038/nrgastro.2017.38
10.1021/acsnano.2c08774
10.1136/gutjnl-2020-323014
10.1016/j.jhep.2012.11.011
10.1002/hep.31658
10.1038/nm0598-594
10.1007/s13577-020-00371-5
10.1089/scd.2012.0395
10.1186/s12964-021-00730-1
10.1186/s12943-019-0991-5
10.1371/journal.pone.0255672
10.1186/s12951-022-01636-x
10.7150/thno.21945
10.1007/s10565-021-09684-z
10.3390/molecules27217289
10.1016/j.isci.2022.104597
10.1186/s13287-022-03049-x
10.1016/j.toxlet.2019.09.008
10.1186/s13287-021-02641-x
10.1002/jcp.1041470105
10.1155/2020/6574010
10.7150/thno.69885
10.1007/s10565-022-09714-4
10.3389/fcell.2021.619565
10.1016/j.gpb.2015.02.001
10.3350/cmh.2020.0194
10.7150/thno.38198
10.1080/20013078.2019.1703244
10.1038/s41467-021-24384-2
10.1080/20013078.2020.1816710
10.1194/jlr.R084343
10.1083/jcb.97.2.329
10.1126/sciadv.abp9435
10.1083/jcb.101.3.942
10.1126/science.aau6977
10.1186/s13287-022-03010-y
10.1038/ncb1596
10.1186/s13287-019-1204-2
10.1038/s41565-020-00836-6
10.1016/j.cca.2022.11.012
10.3389/fcell.2021.716209
10.3390/ijms21134737
10.1016/j.ajpath.2016.07.011
10.1111/jcmm.13208
10.3389/fcimb.2022.857570
10.1186/s10020-020-00207-w
10.1155/2020/8183713
10.1016/j.jhep.2018.09.014
10.1016/j.yexcr.2022.113297
10.1016/j.ijbiomac.2022.05.041
10.3390/cells9040875
10.1096/fj.201902307RRR
10.1002/hep.26768
10.1074/jbc.M116.729202
10.1084/jem.183.3.1161
10.1152/ajpgi.00054.2021
10.1016/S0021-9258(18)48095-7
10.1186/s13287-021-02629-7
10.33549/physiolres.934755
10.3390/ijms20071723
10.2147/IJN.S264498
10.3389/fphar.2022.962525
10.7150/thno.52570
10.1016/j.jhepr.2020.100067
10.1016/0092-8674(83)90040-5
10.1007/s11033-021-07008-2
10.2147/IJN.S291956
10.1139/o92-028
10.3390/cells11101715
10.1016/j.jbc.2021.101266
10.1002/hep.30662
10.3389/fphar.2022.882243
10.1055/s-0040-1708876
10.3390/pharmaceutics10040218
10.1016/j.omtn.2019.01.006
10.1016/j.cbi.2022.109899
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Keywords immune cell
clinical application
liver fibrosis
hepatic stellate cell
exosome
Language English
License Copyright © 2023 Liu, Zheng, Yang, Liu, Wu, Gao and Zhang.
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Edited by: Kinji Asahina, Shiga University of Medical Science, Japan
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
These authors have contributed equally to this work and share first authorship
Reviewed by: Yingxin Zhao, University of Texas Medical Branch at Galveston, United States; Chia-Wei Li, Academia Sinica, Taiwan
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References Marrero (B57) 2022; 419
Tan (B77) 2022; 13
Safran (B35) 2022; 11
Sun (B98) 2021; 12
He (B12) 2018; 8
Pan (B15) 1985; 101
Kwon (B27) 2016; 291
Wang (B48) 2022; 13
Xie (B46) 2022; 71
Wan (B61) 2022; 25
Osawa (B69) 2021; 5
Wu (B80) 2022; 13
Luo (B32) 2021; 70
Peng (B58) 2021; 25
Khan (B71) 2021; 9
Ji (B106) 2022; 10
Picciolini (B109) 2021; 12
Tenchov (B92) 2022; 16
Dong (B44) 2022; 358
Shiha (B84) 2020; 2020
Qu (B101) 2017; 21
Tsai (B93) 2021; 297
Wan (B96) 2022; 8
He (B104) 2022; 12
Chen (B49) 2021; 9
Li (B99) 2013; 58
Jiang (B76) 2018; 2018
Tang (B102) 2021; 35
Li (B75) 2013; 22
Antimisiaris (B91) 2018; 10
Seo (B60) 2016; 64
Lin (B86) 2022; 20
Aydın (B1) 2018; 29
Pan (B70) 2022; 322
Luo (B97) 2021; 28
Roehlen (B2) 2020; 9
Johnstone (B16) 1987; 262
Skotland (B25) 2019; 60
Rajput (B107) 2022; 27
Liang (B29) 2021; 11
Luo (B36) 2021; 27
Watanabe (B82) 2021; 27
Patel (B8) 2020; 2
Mashouri (B24) 2019; 18
Soltani (B108) 2015; 21
Valadi (B21) 2007; 9
Benbow (B56) 2021; 405
Luan (B52) 2022; 211
Liu (B47) 2019; 70
Liu (B38) 2023; 538
Li (B89) 2022; 13
Zitvogel (B20) 1998; 4
Chen (B50) 2020; 34
Devhare (B40) 2017; 91
Wan (B59) 2019; 33
Kim (B41) 2019; 14
Mathieu (B28) 2021; 12
Harding (B14) 1983; 97
Lou (B100) 2017; 21
Lurie (B9) 2015; 21
Ma (B67) 2022; 29
Zhang (B23) 2020; 15
Fang (B53) 2020; 2020
Dai (B43) 2019; 316
Wang (B78) 2021; 19
Johnstone (B18) 1992; 70
Tsuchida (B34) 2017; 14
Wu (B83) 2022; 13
Tan (B5) 2021; 9
Zhang (B26) 2015; 13
Niu (B66) 2021; 9
Catalano (B88) 2020; 9
Chen (B54) 2016; 186
Zhang (B39) 2022
D'Amico (B4) 2018; 12
Feng (B45) 2022; 27
Matsuda (B31) 2020; 40
Wang (B79) 2020; 33
Tang (B103) 2022; 13
Xiao (B68) 2019; 70
Rong (B73) 2019; 10
Hou (B87) 2021; 74
Munich (B30) 2012; 1
Zhou (B51) 2022; 49
Raposo (B19) 1996; 183
Zahmatkesh (B42) 2022; 12
Wang (B64) 2021; 31
Tian (B72) 2022; 13
Asrani (B3) 2019; 70
Wan (B85) 2020; 10
Johnstone (B17) 1991; 147
Baglieri (B6) 2019; 20
Wang (B63) 2020; 26
Chen (B55) 2014; 59
Ma (B74) 2022
Gurung (B22) 2021; 19
Witzigmann (B94) 2020; 159
Duan (B95) 2021; 12
Ye (B90) 2021; 12
Gurunathan (B10) 2021; 16
Kalluri (B11) 2020; 367
Pan (B13) 1983; 33
Huang (B81) 2021; 12
Chang (B65) 2021; 16
Hu (B62) 2021; 16
Li (B105) 2020; 9
Friedman (B33) 2008; 88
Zehra (B7) 2020; 21
Luo (B37) 2021; 26
References_xml – volume: 159
  year: 2020
  ident: B94
  article-title: Lipid nanoparticle technology for therapeutic gene regulation in the liver
  publication-title: Adv Drug Delivery Rev
  doi: 10.1016/j.addr.2020.06.026
– volume: 10
  year: 2022
  ident: B106
  article-title: Clodronate-nintedanib-loaded exosome-liposome hybridization enhances the liver fibrosis therapy by inhibiting kupffer cell activity
  publication-title: Biomater Sci
  doi: 10.1039/d1bm01663f
– volume: 19
  start-page: 437
  year: 2021
  ident: B78
  article-title: 3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-021-01138-2
– volume: 29
  year: 2022
  ident: B67
  article-title: Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis
  publication-title: Drug Delivery
  doi: 10.1080/10717544.2022.2030428
– volume: 91
  year: 2017
  ident: B40
  article-title: Exosome-mediated intercellular communication between hepatitis c virus-infected hepatocytes and hepatic stellate cells
  publication-title: J Virol
  doi: 10.1128/JVI.02225-16
– volume: 12
  year: 2021
  ident: B109
  article-title: Advances in the field of micro- and nanotechnologies applied to extracellular vesicle research: Take-home message from ISEV2021
  publication-title: Micromachines (Basel)
  doi: 10.3390/mi12121563
– volume: 33
  year: 2019
  ident: B59
  article-title: Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: A role for exosomes in metabolic switch of liver nonparenchymal cells
  publication-title: FASEB J
  doi: 10.1096/fj.201802675R
– volume: 9
  start-page: 137
  year: 2021
  ident: B66
  article-title: Exosomal microRNA-155 as a biomarker for hepatic fibrosis diagnosis and progression
  publication-title: Ann Transl Med
  doi: 10.21037/atm-20-7787
– volume: 28
  year: 2021
  ident: B97
  article-title: Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery
  publication-title: Drug Delivery
  doi: 10.1080/10717544.2020.1850917
– volume: 13
  year: 2022
  ident: B83
  article-title: Mesenchymal stem cell-derived extracellular vesicles in liver immunity and therapy
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.833878
– volume: 27
  year: 2021
  ident: B36
  article-title: Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v27.i14.1419
– volume: 64
  year: 2016
  ident: B60
  article-title: Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis
  publication-title: HEPATOLOGY
  doi: 10.1002/hep.28644
– volume: 1
  year: 2012
  ident: B30
  article-title: Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands
  publication-title: ONCOIMMUNOLOGY
  doi: 10.4161/onci.20897
– volume: 13
  year: 2022
  ident: B48
  article-title: A novel miRNA from egg-derived exosomes of schistosoma japonicum promotes liver fibrosis in murine schistosomiasis
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.860807
– volume: 13
  start-page: 319
  year: 2022
  ident: B77
  article-title: HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-022-04764-2
– volume: 27
  year: 2022
  ident: B45
  article-title: Fluid shear stress-induced exosomes from liver cancer cells promote activation of cancer-associated fibroblasts via IGF2-PI3K axis
  publication-title: Front Biosci (Landmark Ed)
  doi: 10.31083/j.fbl2703104
– volume: 405
  year: 2021
  ident: B56
  article-title: Hepatic stellate cell-derived exosomes modulate macrophage inflammatory response
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2021.112663
– volume: 12
  year: 2021
  ident: B90
  article-title: Salidroside inhibits CCl(4)-induced liver fibrosis in mice by reducing activation and migration of HSC induced by liver sinusoidal endothelial cell-derived exosomal SphK1
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2021.677810
– volume: 35
  start-page: e21557
  year: 2021
  ident: B102
  article-title: Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis
  publication-title: FASEB J
  doi: 10.1096/fj.202002777RR
– volume: 5
  year: 2021
  ident: B69
  article-title: Cluster of differentiation 44 promotes liver fibrosis and serves as a biomarker in congestive hepatopathy
  publication-title: Hepatol Commun
  doi: 10.1002/hep4.1721
– volume: 12
  start-page: 34
  year: 2018
  ident: B4
  article-title: New concepts on the clinical course and stratification of compensated and decompensated cirrhosis
  publication-title: Hepatol Int
  doi: 10.1007/s12072-017-9808-z
– volume: 29
  start-page: 14
  year: 2018
  ident: B1
  article-title: Liver fibrosis
  publication-title: TURK J Gastroenterol
  doi: 10.5152/tjg.2018.17330
– volume: 88
  year: 2008
  ident: B33
  article-title: Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00013.2007
– volume: 70
  year: 2019
  ident: B68
  article-title: Long noncoding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia
  publication-title: HEPATOLOGY
  doi: 10.1002/hep.30698
– volume: 25
  year: 2021
  ident: B58
  article-title: DHFR silence alleviated the development of liver fibrosis by affecting the crosstalk between hepatic stellate cells and macrophages
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.16935
– volume: 21
  year: 2015
  ident: B9
  article-title: Non-invasive diagnosis of liver fibrosis and cirrhosis
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v21.i41.11567
– volume: 9
  year: 2021
  ident: B5
  article-title: Liver fibrosis: Therapeutic targets and advances in drug therapy
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.730176
– volume: 12
  year: 2021
  ident: B95
  article-title: Nanoparticle delivery of CRISPR/Cas9 for genome editing
  publication-title: Front Genet
  doi: 10.3389/fgene.2021.673286
– volume: 26
  year: 2021
  ident: B37
  article-title: Hepatocyte-derived exosomal miR-27a activateshepatic stellate cells through the inhibitionof PINK1-mediated mitophagy in MAFLD
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2021.10.022
– volume: 21
  year: 2017
  ident: B101
  article-title: Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.13170
– volume: 21
  year: 2015
  ident: B108
  article-title: Synthetic and biological vesicular nano-carriers designed for gene delivery
  publication-title: Curr Pharm Des
  doi: 10.2174/1381612821666151027153410
– volume: 2018
  year: 2018
  ident: B76
  article-title: Human umbilical cord MSC-derived exosomes suppress the development of CCl(4)-induced liver injury through antioxidant effect
  publication-title: Stem Cells Int
  doi: 10.1155/2018/6079642
– volume: 14
  start-page: 397
  year: 2017
  ident: B34
  article-title: Mechanisms of hepatic stellate cell activation
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/nrgastro.2017.38
– volume: 16
  year: 2022
  ident: B92
  article-title: Exosomes─Nature's lipid nanoparticles, a rising star in drug delivery and diagnostics
  publication-title: ACS NANO
  doi: 10.1021/acsnano.2c08774
– volume: 71
  year: 2022
  ident: B46
  article-title: Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment
  publication-title: GUT
  doi: 10.1136/gutjnl-2020-323014
– volume: 58
  year: 2013
  ident: B99
  article-title: miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2012.11.011
– volume: 74
  year: 2021
  ident: B87
  article-title: Myeloid-Cell-Specific IL-6 signaling promotes MicroRNA-223-Enriched exosome production to attenuate NAFLD-associated fibrosis
  publication-title: HEPATOLOGY
  doi: 10.1002/hep.31658
– volume: 4
  start-page: 594
  year: 1998
  ident: B20
  article-title: Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
  publication-title: Nat Med
  doi: 10.1038/nm0598-594
– volume: 33
  year: 2020
  ident: B79
  article-title: Exosomes derived from natural killer cells inhibit hepatic stellate cell activation and liver fibrosis
  publication-title: Hum Cell
  doi: 10.1007/s13577-020-00371-5
– volume: 22
  year: 2013
  ident: B75
  article-title: Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2012.0395
– volume: 19
  start-page: 47
  year: 2021
  ident: B22
  article-title: The exosome journey: From biogenesis to uptake and intracellular signalling
  publication-title: Cell Commun Signal
  doi: 10.1186/s12964-021-00730-1
– volume: 18
  start-page: 75
  year: 2019
  ident: B24
  article-title: Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
  publication-title: Mol Cancer
  doi: 10.1186/s12943-019-0991-5
– volume: 16
  year: 2021
  ident: B65
  article-title: Clinical impact of serum exosomal microRNA in liver fibrosis
  publication-title: PloS One
  doi: 10.1371/journal.pone.0255672
– volume: 20
  start-page: 432
  year: 2022
  ident: B86
  article-title: Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy
  publication-title: J Nanobiotechnol
  doi: 10.1186/s12951-022-01636-x
– volume: 8
  year: 2018
  ident: B12
  article-title: Exosome theranostics: Biology and translational medicine
  publication-title: THERANOSTICS
  doi: 10.7150/thno.21945
– year: 2022
  ident: B39
  article-title: Exosomes derived from hepatitis b virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis
  publication-title: Cell Biol Toxicol
  doi: 10.1007/s10565-021-09684-z
– volume: 27
  year: 2022
  ident: B107
  article-title: Exosomes as new generation vehicles for drug delivery: Biomedical applications and future perspectives
  publication-title: MOLECULES
  doi: 10.3390/molecules27217289
– volume: 25
  year: 2022
  ident: B61
  article-title: M2 macrophage-derived exosomal microRNA-411-5p impedes the activation of hepatic stellate cells by targeting CAMSAP1 in NASH model
  publication-title: iScience
  doi: 10.1016/j.isci.2022.104597
– volume: 13
  start-page: 494
  year: 2022
  ident: B80
  article-title: ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-022-03049-x
– volume: 316
  start-page: 73
  year: 2019
  ident: B43
  article-title: Exosomal MALAT1 derived from hepatic cells is involved in the activation of hepatic stellate cells via miRNA-26b in fibrosis induced by arsenite
  publication-title: Toxicol Lett
  doi: 10.1016/j.toxlet.2019.09.008
– volume: 12
  start-page: 568
  year: 2021
  ident: B81
  article-title: Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-021-02641-x
– volume: 147
  start-page: 27
  year: 1991
  ident: B17
  article-title: Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.1041470105
– volume: 2020
  year: 2020
  ident: B84
  article-title: Antifibrotic effect of combination of nilotinib and stem cell-conditioned media on CCl(4)-induced liver fibrosis
  publication-title: Stem Cells Int
  doi: 10.1155/2020/6574010
– volume: 12
  year: 2022
  ident: B104
  article-title: Exosome-mediated delivery of RBP-J decoy oligodeoxynucleotides ameliorates hepatic fibrosis in mice
  publication-title: THERANOSTICS
  doi: 10.7150/thno.69885
– year: 2022
  ident: B74
  article-title: hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B
  publication-title: Cell Biol Toxicol
  doi: 10.1007/s10565-022-09714-4
– volume: 9
  year: 2021
  ident: B71
  article-title: Native and bioengineered exosomes for ischemic stroke therapy
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.619565
– volume: 13
  start-page: 17
  year: 2015
  ident: B26
  article-title: Exosome and exosomal microRNA: trafficking, sorting, and function
  publication-title: Genomics Proteomics Bioinf
  doi: 10.1016/j.gpb.2015.02.001
– volume: 27
  start-page: 70
  year: 2021
  ident: B82
  article-title: The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future
  publication-title: Clin Mol Hepatol
  doi: 10.3350/cmh.2020.0194
– volume: 10
  year: 2020
  ident: B85
  article-title: Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium
  publication-title: THERANOSTICS
  doi: 10.7150/thno.38198
– volume: 9
  year: 2020
  ident: B88
  article-title: Inhibiting extracellular vesicles formation and release: A review of EV inhibitors
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2019.1703244
– volume: 12
  start-page: 4389
  year: 2021
  ident: B28
  article-title: Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-24384-2
– volume: 9
  year: 2020
  ident: B105
  article-title: Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: A proof-of-concept study
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2020.1816710
– volume: 60
  start-page: 9
  year: 2019
  ident: B25
  article-title: Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology
  publication-title: J Lipid Res
  doi: 10.1194/jlr.R084343
– volume: 97
  year: 1983
  ident: B14
  article-title: Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
  publication-title: J Cell Biol
  doi: 10.1083/jcb.97.2.329
– volume: 8
  year: 2022
  ident: B96
  article-title: Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases
  publication-title: Sci Adv
  doi: 10.1126/sciadv.abp9435
– volume: 101
  year: 1985
  ident: B15
  article-title: Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
  publication-title: J Cell Biol
  doi: 10.1083/jcb.101.3.942
– volume: 367
  year: 2020
  ident: B11
  article-title: The biology, function, and biomedical applications of exosomes
  publication-title: SCIENCE
  doi: 10.1126/science.aau6977
– volume: 13
  year: 2022
  ident: B72
  article-title: Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-022-03010-y
– volume: 9
  year: 2007
  ident: B21
  article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1596
– volume: 10
  start-page: 98
  year: 2019
  ident: B73
  article-title: Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the wnt/β-catenin pathway
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-019-1204-2
– volume: 31
  year: 2021
  ident: B64
  article-title: Using next-generation sequencing to identify novel exosomal miRNAs as biomarkers for significant hepatic fibrosis
  publication-title: Discovery Med
– volume: 16
  year: 2021
  ident: B62
  article-title: Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis
  publication-title: Nat NANOTECHNOL
  doi: 10.1038/s41565-020-00836-6
– volume: 538
  start-page: 5
  year: 2023
  ident: B38
  article-title: Exosomes in HBV infection
  publication-title: Clin Chim Acta
  doi: 10.1016/j.cca.2022.11.012
– volume: 9
  year: 2021
  ident: B49
  article-title: Exosomal miR-500 derived from lipopolysaccharide-treated macrophage accelerates liver fibrosis by suppressing MFN2
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.716209
– volume: 21
  year: 2020
  ident: B7
  article-title: Elucidating potential profibrotic mechanisms of emerging biomarkers for early prognosis of hepatic fibrosis
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21134737
– volume: 186
  year: 2016
  ident: B54
  article-title: Fibrogenic signaling is suppressed in hepatic stellate cells through targeting of connective tissue growth factor (CCN2) by cellular or exosomal MicroRNA-199a-5p
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2016.07.011
– volume: 21
  year: 2017
  ident: B100
  article-title: MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.13208
– volume: 12
  year: 2022
  ident: B42
  article-title: Effects of exosomes derived from helicobacter pylori outer membrane vesicle-infected hepatocytes on hepatic stellate cell activation and liver fibrosis induction
  publication-title: Front Cell Infect Microbiol
  doi: 10.3389/fcimb.2022.857570
– volume: 26
  start-page: 81
  year: 2020
  ident: B63
  article-title: Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy
  publication-title: Mol Med
  doi: 10.1186/s10020-020-00207-w
– volume: 2020
  year: 2020
  ident: B53
  article-title: ASK1 enhances angiotensin II-induced liver fibrosis in vitro by mediating endoplasmic reticulum stress-dependent exosomes
  publication-title: Mediators Inflammation
  doi: 10.1155/2020/8183713
– volume: 70
  year: 2019
  ident: B3
  article-title: Burden of liver diseases in the world
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2018.09.014
– volume: 419
  year: 2022
  ident: B57
  article-title: Ectodysplasin-a mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2022.113297
– volume: 211
  year: 2022
  ident: B52
  article-title: ASIC1a promotes hepatic stellate cell activation through the exosomal miR-301a-3p/BTG1 pathway
  publication-title: Int J Biol MACROMOL
  doi: 10.1016/j.ijbiomac.2022.05.041
– volume: 9
  year: 2020
  ident: B2
  article-title: Liver fibrosis: Mechanistic concepts and therapeutic perspectives
  publication-title: CELLS-BASEL
  doi: 10.3390/cells9040875
– volume: 34
  year: 2020
  ident: B50
  article-title: Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells
  publication-title: FASEB J
  doi: 10.1096/fj.201902307RRR
– volume: 59
  year: 2014
  ident: B55
  article-title: Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells
  publication-title: HEPATOLOGY
  doi: 10.1002/hep.26768
– volume: 291
  year: 2016
  ident: B27
  article-title: Adaptor protein CD2AP and l-type lectin LMAN2 regulate exosome cargo protein trafficking through the golgi complex
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.729202
– volume: 183
  year: 1996
  ident: B19
  article-title: B lymphocytes secrete antigen-presenting vesicles
  publication-title: J Exp Med
  doi: 10.1084/jem.183.3.1161
– volume: 322
  year: 2022
  ident: B70
  article-title: The therapeutic potential of exosomes derived from different cell sources in liver diseases
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00054.2021
– volume: 262
  year: 1987
  ident: B16
  article-title: Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)48095-7
– volume: 12
  start-page: 561
  year: 2021
  ident: B98
  article-title: Mesenchymal stem cells-derived exosomes for drug delivery
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-021-02629-7
– volume: 70
  year: 2021
  ident: B32
  article-title: Hepatic stellate cell: A double-edged sword in the liver
  publication-title: Physiol Res
  doi: 10.33549/physiolres.934755
– volume: 20
  year: 2019
  ident: B6
  article-title: The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20071723
– volume: 15
  year: 2020
  ident: B23
  article-title: Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S264498
– volume: 13
  year: 2022
  ident: B89
  article-title: Traditional Chinese medicine: An important source for discovering candidate agents against hepatic fibrosis
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2022.962525
– volume: 11
  year: 2021
  ident: B29
  article-title: Engineering exosomes for targeted drug delivery
  publication-title: THERANOSTICS
  doi: 10.7150/thno.52570
– volume: 2
  year: 2020
  ident: B8
  article-title: Limitations of non-invasive tests for assessment of liver fibrosis
  publication-title: JHEP Rep
  doi: 10.1016/j.jhepr.2020.100067
– volume: 33
  year: 1983
  ident: B13
  article-title: Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
  publication-title: CELL
  doi: 10.1016/0092-8674(83)90040-5
– volume: 49
  year: 2022
  ident: B51
  article-title: Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-021-07008-2
– volume: 16
  year: 2021
  ident: B10
  article-title: A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S291956
– volume: 70
  year: 1992
  ident: B18
  article-title: The Jeanne manery-Fisher memorial lecture 1991. maturation of reticulocytes: Formation of exosomes as a mechanism for shedding membrane proteins
  publication-title: Biochem Cell Biol
  doi: 10.1139/o92-028
– volume: 11
  year: 2022
  ident: B35
  article-title: Extracellular vesicular transmission of miR-423-5p from HepG2 cells inhibits the differentiation of hepatic stellate cells
  publication-title: CELLS-BASEL
  doi: 10.3390/cells11101715
– volume: 297
  year: 2021
  ident: B93
  article-title: Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity
  publication-title: J Biol Chem
  doi: 10.1016/j.jbc.2021.101266
– volume: 70
  year: 2019
  ident: B47
  article-title: Cholangiocyte-derived exosomal long noncoding RNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis
  publication-title: HEPATOLOGY
  doi: 10.1002/hep.30662
– volume: 13
  year: 2022
  ident: B103
  article-title: Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2022.882243
– volume: 40
  year: 2020
  ident: B31
  article-title: Hepatic stellate cell-macrophage crosstalk in liver fibrosis and carcinogenesis
  publication-title: Semin LIVER Dis
  doi: 10.1055/s-0040-1708876
– volume: 10
  year: 2018
  ident: B91
  article-title: Exosomes and exosome-inspired vesicles for targeted drug delivery
  publication-title: PHARMACEUTICS
  doi: 10.3390/pharmaceutics10040218
– volume: 14
  year: 2019
  ident: B41
  article-title: Exosomal transmission of MicroRNA from HCV replicating cells stimulates transdifferentiation in hepatic stellate cells
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2019.01.006
– volume: 358
  year: 2022
  ident: B44
  article-title: Exosomal miR-181a-2-3p derived from citreoviridin-treated hepatocytes activates hepatic stellate cells trough inducing mitochondrial calcium overload
  publication-title: Chem Biol Interact
  doi: 10.1016/j.cbi.2022.109899
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Snippet Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play...
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SubjectTerms Cell Communication
clinical application
exosome
Exosomes
Exosomes - metabolism
hepatic stellate cell
Hepatic Stellate Cells
Hepatic Stellate Cells - metabolism
Hepatocytes
Hepatocytes - metabolism
Humans
immune cell
Immunologic diseases. Allergy
Immunology
Liver Cirrhosis
Liver Cirrhosis - pathology
liver fibrosis
RC581-607
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  priority: 102
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Title Exosomes in liver fibrosis: The role of modulating hepatic stellate cells and immune cells, and prospects for clinical applications
URI https://cir.nii.ac.jp/crid/1871428067797408000
https://www.ncbi.nlm.nih.gov/pubmed/37020547
https://www.proquest.com/docview/2797146529
https://pubmed.ncbi.nlm.nih.gov/PMC10067730
https://doaj.org/article/40b6284febaf4687acc74b8096133495
Volume 14
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