Dengue virus pathogenesis and host molecular machineries

• Published in: Journal of biomedical science Vol. 31; no. 1; pp. 43 - 24
• Main Authors: Sinha, Saumya, Singh, Kinjal, Ravi Kumar, Y. S., Roy, Riya, Phadnis, Sushant, Meena, Varsha, Bhattacharyya, Sankar, Verma, Bhupendra
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.04.2024; BioMed Central; BMC
• Subjects: Animals; Antibodies; Aquatic insects; Biodegradation; Biological activity; Cell cycle; Culicidae; Cytokine storm; Dengue - virology; Dengue fever; Dengue hemorrhagic fever; Dengue virus; Dengue Virus - genetics; Dengue Virus - pathogenicity; Dengue Virus - physiology; Dengue viruses; Development and progression; Disease transmission; DNA methylation; Epigenetic inheritance; Epigenetics; Epigenomic regulation; Flaviviridae; Gene expression; Gene regulation; Genes; Genetic transcription; Genetic translation; Genomes; Genomics; Health aspects; Hemorrhagic fever; Host-Pathogen Interactions; Humans; Immune system; Infection; Infections; Medical prognosis; Messenger RNA; Mortality; Mosquitoes; Pathogenesis; Physiological aspects; Post-transcription; Post-transcriptional modifications; Post-translation; Post-translational modifications; Proteins; Proteolysis; Regulatory mechanisms (biology); Replication; Review; RNA polymerase; RNA viruses; Transcription regulation; Transcriptomes; Translation regulation; Vaccines; Vector-borne diseases; Viral diseases; Viral infections; Viral proteins; Virus Replication; Viruses; Post-translational modifications; Epigenomic regulation; Stress granule formation; Translation regulation; Post-transcriptional modifications; Dengue virus; Transcription regulation

Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of t...