EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer

• Published in: Molecular cancer Vol. 22; no. 1; pp. 85 - 15
• Main Authors: Chen, Jianfeng, Hong, Jing Han, Huang, Yulin, Liu, Shini, Yin, Jiaxin, Deng, Peng, Sun, Yichen, Yu, Zhaoliang, Zeng, Xian, Xiao, Rong, Chan, Jason Yongsheng, Guan, Peiyong, Wang, Yali, Wang, Peili, Liu, Lizhen, Wen, Shijun, Yu, Qiang, Ong, Choon Kiat, Teh, Bin-Tean, Xiong, Ying, Tan, Jing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.05.2023; BioMed Central; BMC
• Subjects: Analysis; Catalysis; Cell growth; Cell Line, Tumor; Cell proliferation; Chromatin; Development and progression; Enhancer of Zeste Homolog 2 Protein - genetics; EZH2; Female; Genomics; Growth; Health aspects; Histone methyltransferase; Histones; Histones - metabolism; Humans; IDH2; Immunohistochemistry; Immunoprecipitation; Laboratory animals; Medical prognosis; Metabolic rewiring; Metabolism; Methylation; Methyltransferases; Ovarian cancer; Ovarian Neoplasms - pathology; Polycomb group proteins; Polycomb Repressive Complex 2 - genetics; Polycomb Repressive Complex 2 - metabolism; Prostate cancer; RNA sequencing; TCA cycle; Transcriptomes; Tricarboxylic acid cycle; Tumorigenesis; Tumorigenicity; Tumors; China; Metabolic rewiring; TCA cycle; IDH2; EZH2; Ovarian cancer

Enhancer of zeste homolog 2 (EZH2), the key catalytic subunit of polycomb repressive complex 2 (PRC2), is overexpressed and plays an oncogenic role in various cancers through catalysis-dependent or catalysis-independent pathways. However, the related mechanisms contributing to ovarian cancer (OC) ar...