Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD

• Published in: Journal of neuroinflammation Vol. 20; no. 1; pp. 74 - 11
• Main Authors: Gu, Dongmei, Wang, Luchun, Zhang, Nan, Wang, Huali, Yu, Xin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.03.2023; BioMed Central; BMC
• Subjects: Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides; Amyloidosis; Analysis; Antibodies; Antigens; Apoptosis; Biological markers; Biomarkers; Brain; Care and treatment; Cognitive ability; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - genetics; Dementia; Development and progression; Disease Progression; Education; Epitopes; Gene expression; Gene set enrichment analysis; Genetic aspects; Genomes; Health aspects; Hospitals; Humans; Immune system; Immunity; Immunoglobulins; Lymphocytes B; Memory; Mental disorders; Mental health; Natural antibodies; Neurodegeneration; Neurodegenerative diseases; Pathogenesis; Peptides; Phagocytosis; Physiology; Plasma; Plasma biomarkers; Proteins; Testing; Viral antibodies; China; Natural antibodies; Alzheimer’s disease; Plasma biomarkers; Immunity; Phagocytosis

Naturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as apoptotic and necrotic cells. However, NAbs pathological relevance in Alzheimer's disease (AD) is not well-understood. Twenty-eight candidate proteins encoded b...