Four-year clinical update from a prospective trial of accelerated partial breast intensity-modulated radiotherapy (APBIMRT)

• Published in: Breast cancer research and treatment Vol. 140; no. 1; pp. 119 - 133
• Main Authors: Lei, Rachel Y., Leonard, Charles E., Howell, Kathryn T., Henkenberns, Phyllis L., Johnson, Timothy K., Hobart, Tracy L., Fryman, Shannon P., Kercher, Jane M., Widner, Jodi L., Kaske, Terese, Carter, Dennis L.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2013; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast cancer; Breast Neoplasms - mortality; Breast Neoplasms - radiotherapy; Cancer research; Cancer surgery; Cancer therapies; Carcinoma, Ductal, Breast - mortality; Carcinoma, Ductal, Breast - radiotherapy; Clinical Trial; Female; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Multivariate Analysis; Nuclear radiation; Oncology; Pain - etiology; Radiation therapy; Radioisotope brachytherapy; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated - adverse effects; Treatment Outcome; Tumors; Accelerated partial breast irradiation; Adjuvant radiotherapy; Breast cancer; Intensity-modulated radiotherapy; Breast-conserving therapy; Breast disease; Adjuvant treatment; Updating; Malignant tumor; Prospective; Mammary gland diseases; Intensity modulated radiotherapy; Partial; Irradiation; Breast; Clinical trial; Mammary gland; Cancer

This prospective Phase II single-arm study gathered data on the use of intensity-modulated radiotherapy (IMRT) to deliver accelerated partial breast irradiation (APBI). Four-year efficacy, cosmesis, and toxicity results are presented. Between February 2004 and September 2007, 136 consecutive patient...