Differential expression of PSD proteins in age-related spatial learning impairments

• Published in: Neurobiology of aging Vol. 28; no. 1; pp. 143 - 155
• Main Authors: Nyffeler, Myriel, Zhang, Wei-Ning, Feldon, Joram, Knuesel, Irene
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.01.2007; Elsevier Science
• Subjects: Aging - metabolism; Aging - pathology; AMPA receptor GluR1; Animals; Bassoon; Biological and medical sciences; Dentate gyrus; Development. Senescence. Regeneration. Transplantation; Fundamental and applied biological sciences. Psychology; Gene Expression; Hippocampus; Hippocampus - pathology; Hippocampus - physiopathology; Immunohistochemistry; Internal Medicine; Learning Disorders - pathology; Learning Disorders - physiopathology; Male; Memory Disorders - pathology; Memory Disorders - physiopathology; Nerve Tissue Proteins - metabolism; Neurology; Postsynaptic density; PSD-95; Rat; Rats; Rats, Wistar; Reference memory; Synapses - metabolism; Synapses - pathology; synGAP; Vertebrates: nervous system and sense organs; Water maze; Working memory; αCaMKII; Reference memory; Immunohistochemistry; Rat; Bassoon; Dentate gyrus; Water maze; synGAP; Postsynaptic density; Working memory; AMPA receptor GluR1; PSD-95; αCaMKII; Hippocampus; Central nervous system; Glutamate receptor; Cognition; Space perception; Genetic determinism; Encephalon; aCaMKII; Acquisition process; Genetics; Age; Rodentia; Gene expression; Vertebrata; AMPA receptor; Mammalia; Animal; Perceptive learning

Deficits in hippocampus-dependent spatial learning that are typical for a subpopulation of aged rats are not associated with loss of neurons or excitatory synapses but accompanied by significant reduction of postsynaptic density (PSD) area in perforated synapses. Here, we examined whether structural...